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  • Author: Z. Tian x
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M. Zheng, H. Gao, H. Teng, J. Hu, Z. Tian and Y. Zhao

Abstract

In this article, it aims to propose effective approaches for hydro-forming process of bi-metallic composite pipe by assuming plane strain and elastic-perfectly plastic material model. It derives expressions for predicting hydro-forming pressure and residual stress of the forming process of bi-metallic composite pipe. Test data from available experiments is employed to check the model and formulas. It shows the reliability of the proposed model and formulas impersonally.

Open access

X. F. Yang, Z. Y. Jiang, Z. M. Tian, Y. Q. Qiu, L. Wang, K. G. Gao, Y. J. Hu and X. Y. Ma

Abstract

The uneven development of adipose tissues reflects a differential occurrence of biological events in vivo while the underlying molecular mechanism remains largely unknown. In the present study, the in vivo inflammatory status of an inbred obese porcine model, Lantang pig, was assessed, aiming to provide evidence for obesity biology. Compared with genetically lean pigs (crossbred, Duroc × Landrace × Large White), Lantang pigs exhibited a larger amount of ultra large adipocytes in subcutaneous adipose tissue accompanied with higher expression of macrophage/monocytes markers and pro-inflammatory genes (TLR4, CD14, CD11β, MCP1, TNFα, IL1β and IL6) and lower expression of cellular antioxidant enzymes (SOD1, 2 and 3). Plasma concentrations of LPS and TNF-α were also higher in Lantang pigs than in lean pigs. Among adipose tissues of Lantang pigs, the subcutaneous tissue had the most abundant expression of inflammation related genes (TLR4, CD14, TNFα and IL6) and the lowest level of cellular antioxidant genes (SOD 1 and 2), while the perirenal adipose tissue had opposite profile. Significant activation of p38 MAPK pathway was indicated by increased phosphorylation of p38 in the subcutaneous adipose tissue of Lantang pigs. Collectively, the bacteria-derived LPS induced inflammation-associated oxidative stress indeed exists in adipose tissues of Lantang pig, and the differential expressions of inflammatory and antioxidant genes, to some extent, account for the uneven development of the adipose tissue within bodies.

Open access

Liu Bin, Meng Zhang, Liu Lixia, Zang Aimin, Yang Hua, Shang Yanhong, Yang Yang, Gao Feng, Liu Bo, Zhang Yonggang and Tian Huiping

Abstract

Background: MiRNA-30c was a tumor suppressor in several human cancers, however, its association with clinicopathological features and prognosis in colorectal cancer (CRC) is unclear.

Materials and Methods: The expression level of miRNA-30c in 192 pairs of colorectal cancer and adjacent normal tissues was detected by Quantitative RT-PCR, the association between miRNA-30c expression and clinical characteristics and prognosis were statistically analyzed.

Results: miRNA-30c was significantly lower in CRC tissues specimens compared with matched normal adjacent tissue (P<0.001). MiRNA-30c was positively correlated with tumor size (P=0.012), TMN stage (P=0.002) and lymph node metastasis (P=0.004). The univariate analysis showed CRC patients with low miRNA-30c had distinctly shorter overall survival (P<0.001) than patients with high miRNA-30c expression level. The multivariate analysis was performed and informed that low miRNA-30c expression (P<0.001) might be an independent prognostic predictor for poor prognosis.

Conclusion: miRNA-30c could predict the prognosis of colorectal cancer which is helpful to choose reasonable treatment measures.