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  • Author: Yuxin Han x
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An Influence Prediction Model for Microblog Entries on Public Health Emergencies

Abstract

This study aims at constructing a microblog influence prediction model and revealing how the user, time, and content features of microblog entries about public health emergencies affect the influence of microblog entries. Microblog entries about the Ebola outbreak are selected as data sets. The BM25 latent Dirichlet allocation model (LDA-BM25) is used to extract topics from the microblog entries. A microblog influence prediction model is proposed by using the random forest method. Results reveal that the proposed model can predict the influence of microblog entries about public health emergencies with a precision rate reaching 88.8%. The individual features that play a role in the influence of microblog entries, as well as their influence tendencies are also analyzed. The proposed microblog influence prediction model consists of user, time, and content features. It makes up the deficiency that content features are often ignored by other microblog influence prediction models. The roles of the three features in the influence of microblog entries are also discussed.

Open access
Xylazine regulates the release of glycine and aspartic acid in rat brain

Abstract

Introduction

Xylazine, a type of α2-adrenoceptors, is a commonly used drug in veterinary medicine. Xylazine-induced changes in the content of amino acid neurotransmitters – glycine (Gly) and aspartic acid (Asp), in different brain regions and neurons were studied.

Material and Methods

Wistar rats were administered 50 mg/kg or 70 mg/kg of xylazine by intraperitoneal injection. In addition, in vitro experiments were conducted, in which neurons were treated with 15 μg/mL, 25 μg/mL, 35μg/mL, and 45 μg/mL of xylazine. Test methods were based on the enzyme-linked immunosorbent assays (ELISA).

Results

During anaesthesia, Asp levels in each brain area were significantly lower compared to the control group. Except for the cerebrum, levels of Gly in other brain areas were significantly increased during the anaesthesia period. In vitro, xylazine-related neuron secretion of Gly increased significantly compared to the control group at 60 min and 90 min. Moreover, xylazine caused a significant decrease in the levels of Asp secreted by neurons at 20 min, but gradually returned to the level of the control group.

Conclusion

The data showed that during anaesthesia the overall levels of Asp decreased and overall levels of Gly increased. In addition, the inhibitory effect of xylazine on Asp and the promotion of Gly were dose-dependent. Our data showed that different effects of xylazine on excitatory and inhibitory neurotransmitters provided a theoretical basis for the mechanism of xylazine activity in clinical anaesthesia.

Open access