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Yusuf Hassan, Rosa Klein and Perry T. Kaye

Abstract

Four new chiral ketopinic acid-derived catalysts were anchored on a polystyrene-bound imidazole via non-covalent bond. The resulting heterogeneous catalysts were successfully characterized using IR, SEM, and TGA analyses.

Open access

Yusuf Hassan, Rosa Klein and Perry T. Kaye

Abstract

A new manganese complex was synthesised incorporating 1,2-diaminobenzene linked ketopinic acid scaffold, and successfully utilised as catalyst in the aldol condensation reactions of benzaldehyde with various aliphatic ketones to obtain products with excellent yield of >99 %.

Open access

Yusuf Hassan, Rosa Klein and Perry T. Kaye

Abstract

A complex of manganese (III) and R,R-1,2-Diaminocyclohexane linked ketopinic acid ligand was synthesized and utilised as catalyst in the aldol condensation reactions of benzaldehyde with various aliphatic ketones to furnish products with excellent yield of > 99%.

Open access

Amina S. Yusuf, Ibrahim Sada, Yusuf Hassan, Temitope O. Olomola, Christiana M. Adeyemi and Sunday O. Ajibade

Abstract

The synthesis of five monocarbonyl analogues of curcumin is described. In vitro anti-malarial assay of the compounds was carried out and the effect of the substituents on the aryl ring has been described. The results show that all the five compounds exhibited some reasonable activity against the chloroquine-resistant plasmodium parasite. Molecular docking studies further confirmed the observed biological activity of the compounds.