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  • Author: Yu-feng Gao x
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Single Nucleotide Polymorphisms rs2227284, rs2243283 and rs2243288 in the IL-4 Gene Show no Association with Susceptibility to Chronic Hepatitis B in a Chinese Han Population

Abstract

Objective To investigate the relationship between single nucleotide polymorphisms (SNPs) of the interleukin-4 (IL-4) gene and outcome of hepatitis B virus (HBV) infection in a Chinese Han population.

Methods Total of 501 patients with chronic hepatitis B virus (HBV) infection and 301 controls with selflimiting HBV infection were studied. Three tag SNPs in the IL-4 gene (rs2227284G/T, rs2243283C/G and rs2243288A/G) were genotyped by the Multiplex snapshot technique. The genotype and allele frequencies were calculated and analyzed.

Results The three SNPs showed no significant genotype/allele associations with chronic HBV infection. Overall allele P values were: rs2227284, P = 0.655, odds ratio (OR) [95% confidence interval (CI)] = 1.070 (0.793-1.445); rs2243283, P = 0.849, OR (95% CI) = 0.976 (0.758-1.257); rs2243288, P = 0.659, OR (95% CI) = 1.060 (0.818-1.375). Overall genotype P values were: rs2227284, P = 0.771; rs2243283, P = 0.571; rs2243288, P = 0.902. There were no statistically significant differences between patients with chronic HBV infection and controls. Haplotypes generated by these three SNPs also had no significant differences between the two groups.

Conclusions The three tag SNPs of IL-4 were not associated with the outcome of HBV infection in the Han Chinese population.

Open access
Lower left lung abscess from combined stomach and left diaphragm perforation by an intragastric foreign body

Abstract

Background: Usually children mistakenly swallow foreign bodies, and most objects are spontaneously discharged through the digestive tract without consequence. However, sometimes the objects can cause gastrointestinal perforation, with serious complications.

Objective: To report the case of a 26-year-old male patient, who mistakenly swallowed a bamboo chopstick 14 years ago. The chopstick eventually perforated the gastric fundus and left diaphragm, pierced the lower left lobe of the lung, and caused a lower left lung abscess.

Method: A thoracotomy was conducted to remove the foreign body and the lower left lobe of the lung, followed by a patch fundoplication.

Result: The object was removed and the patient’s lesions healed after surgery.

Conclusion: The ingestion of foreign bodies rarely causes serious problems, but we should be vigilant to the occurrence of complications, and close follow-up should be conducted. This follow-up should include confirmation that the foreign body has passed through the alimentary tract.

Open access