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  • Author: Yu-Xin Wang x
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Open access

Xue Wang, Shuaishuai Huang, Xia Xin, Yu Ren, Guobin Weng and Ping Wang

Abstract

Umbelliferone exhibits extensive pharmacological activity, including anti-immunomodulatory, anti-inflammatory and antigenotoxicity activities. However, its antitumor properties still remain unclear in human renal cell carcinoma (RCC) cells. Our results have revealed that treatment of human RCC cells (786-O, OS-RC-2, and ACHN) with umbelliferone reduced cell proliferation in a concentration-dependent manner and induced dose-dependent apoptotic events. In addition, cell cycle analysis determined that umbelliferone treatment induced cell cycle arrest in the G1 phase in a dose-dependent manner. Furthermore, western blotting analysis showed a dose-dependent decrease in Ki67, MCM2, Bcl-2, CDK2, CyclinE1, CDK4, and CyclinD1 and a dose-dependent increase in Bax in RCC cells cultured with umbelliferone. Similarly, umbelliferone exhibited a dose-dependent reduction of p110γ when using western blotting analyses. Taken together, these results provide an insight into the pharmacology regarding the potential application of umbelliferone, which contributes to cell death by decreasing p110γ protein expression.

Open access

Xin-Hua Wang, Yu-Lin Jiao, Yong-Chao Niu and Jie Yang

Abstract

Traditional wavelet denoising method cannot eliminate complex high-pressure pipe signals effectively. In the updated wavelet adaptive algorithm, this thesis defines the constraints in order to reconstruct the signals accurately. According to the minimum mean square error criterion, the results predict the weight coefficient and get the optimal linear predictive value. Adopting the improved algorithm under the same condition, this thesis concluded that Db6 increased the complexity of wavelet algorithm by 50% by comparative experiments. It will be more conducive to the realization of hardware and the feasibility of real-time denoising. Dual adaptive wavelet denoising method improved SNR by 50%. This denoising method will play a key role in the detection rate of high-pressure pipe in the online leakage detection system.

Open access

Jian-Ping Yu, Wen Wang, Xin Li and Zhao-Zhong Zhou

Abstract

This paper presents a novel phase-shift arctangent (PSA) interpolation method to improve the measurement accuracy of a planar capacitive incremental displacement sensor. Signals of planar capacitive micro-sensors acquire waveform errors, including sensitivity differences and phase-shift errors, because of static errors and dynamic disturbances. In the proposed PSA scheme, such errors are removed completely by loading a particular arctangent function. Moreover, measuring efficiency of the proposed planar capacitive sensors is improved by combining coarse measurement and fine estimation. Experiments show unanimous results to model-based fitting. When electrode length is four times the gap distance, applying the PSA interpolation method decreases waveform errors from more than 4 % to 1.72 %.

Open access

Yi-Ming Zhang, Dong-Xu Yu, Bai-Shuang Yin, Xin-Ran Li, Li-Na Li, Ya-Nan Li, Yu-Xin Wang, Yu Chen, Wen-Han Liu and Li Gao

Abstract

Introduction: Xylazine, a type of α2-adrenoceptors, is a commonly used drug in veterinary medicine. Xylazine-induced changes in the content of amino acid neurotransmitters – glycine (Gly) and aspartic acid (Asp), in different brain regions and neurons were studied.

Material and Methods: Wistar rats were administered 50 mg/kg or 70 mg/kg of xylazine by intraperitoneal injection. In addition, in vitro experiments were conducted, in which neurons were treated with 15 μg/mL, 25 μg/mL, 35 μg/mL, and 45 μg/mL of xylazine. Test methods were based on the enzyme-linked immunosorbent assays (ELISA).

Results: During anaesthesia, Asp levels in each brain area were significantly lower compared to the control group. Except for the cerebrum, levels of Gly in other brain areas were significantly increased during the anaesthesia period. In vitro, xylazine-related neuron secretion of Gly increased significantly compared to the control group at 60 min and 90 min. Moreover, xylazine caused a significant decrease in the levels of Asp secreted by neurons at 20 min, but gradually returned to the level of the control group.

Conclusion: The data showed that during anaesthesia the overall levels of Asp decreased and overall levels of Gly increased. In addition, the inhibitory effect of xylazine on Asp and the promotion of Gly were dose-dependent. Our data showed that different effects of xylazine on excitatory and inhibitory neurotransmitters provided a theoretical basis for the mechanism of xylazine activity in clinical anaesthesia.

Open access

Yi-Fan Tang, Xin-Yu Hu, Jing Zhao, Ze-Juan Gu, Shuang-Shuang Xing and Wei-Yun Wang

Abstract

Objective

Venous leg ulceration (VLU) is one of the complications of lower extremity venous reflux and reflux disorder of severe diseases, with many adverse effects on patient’s work and life. Nowadays, more and more patients with VLU accept wound care in community setting. Clinical nurses generally take care of the patients based on their own experiences. Healing in VLU is an incredibly complex process, which puzzles even experts. The majority of general nurses do not have this level of expertise, especially those nurses serving in community. Function is the basis of nursing activities. Patients always show different clinical manifestations and self-care abilities due to various function states, which cannot be reflected completely by the existing nursing practice. How to describe nursing practice standardized in order to demonstrate the effectiveness of interventions and facilitate interdisciplinary communication is another urgent problem. Therefore, the aim of this project is to develop an accurate nursing program based on function in chronic venous leg ulcers, which can both satisfy the needs of patients and promote nursing revolution.

Methods

This study will use International Classification of Functioning Disability and Health as a framework to choose suitable functions and to filter function classification standards of chronic venous leg ulcers through evidence-based systematic research. Nursing interventions related to VLU are selected based on Nursing Interventions Classification, adding other nursing activities by methods of evidence-based systematic review and clinical observation. Then, nursing interventions and function status are matched through steering committee. Finally, the Delphi survey method is adopted to make nursing program native and scientific.

Conclusions

This study is expected to be very significant and meaningful in using standardized nursing terminology. The nursing program established could better meet the needs of both patients with chronic venous leg ulcers and clinical nurses, promoting the development of wound specialist and standardized nursing language.

Open access

Jian-ming Zheng, Ming-quan Chen, Meng-qi Zhu, Ning Li, Qian Li, Xin-yu Wang, Chong Huang and Guang-feng Shi

Abstract

Objective To assess on-treatment serum HBsAg and HBV DNA kinetics in HBeAg-positive CHB patients to predict the efficacy of pegylated interferon (PEG-IFN) in early phase of treatment.

Methods Forty-one treatment-naive HBeAg-positive patients treated with PEG-IFNα 2a at a dose of 180 μg/week for at least 24 weeks were evaluated. Their treatment response was assessed, including normalization of serum ALT, decline of serum HBV DNA and loss of HBeAg.

Results We found that a decrease of HBV DNA level at the 4th week was positively correlated with the decrease of HBV DNA level at the 12th week and 24th week (r = 0.8202, P < 0.0001 and r = 0.6838, P < 0.0001, respectively). We observed that a decrease of HBsAg level at the 4th week was positively correlated with decrease of HBsAg level at the 12th week and 24th week (r = 0.4868, P = 0.0023 and r = 0.4251, P = 0.0109, respectively). A decrease of HBsAg level at the 24th week was positively correlated with the decrease of HBV DNA level at the 24th week (r = 0.5262, P = 0.0024). Serum level of IFN and IFN neutralizing antibody had no relationship with HBV DNA or HBsAg titers kinetics.

Conclusions The decline of serum HBV DNA and hepatitis B surface antigen at the 4th week can be used to predict the response to PEG-IFNα 2a in patients with HBeAg positive chronic hepatitis B.