The purpose of this study was to investigate college students on their speed of performing different types of self-defense skills commonly taught in American university self-defense courses. The results indicated that close defense skills and distance punches are faster than distance kicks in most single skills or combination skills. Women can do most skills as fast as men. The results also indicated that all kicks with back-foot are slower than kicks with front-foot in distance defense. Women need 2.42- 6.12 seconds to escape from all 20 holds, while men need 1.14-5.54 seconds for people who successfully escaped. Escaping from different holds is not as difficult as what most people think. After proper learning and practice, a majority of college women and men can escape from many holds in 1-6 seconds.