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Open access

Yong Deng, Yibing Shi and Wei Zhang

Diagnosis of Incipient Faults in Nonlinear Analog Circuits

Considering the problem to diagnose incipient faults in nonlinear analog circuits, a novel approach based on fractional correlation is proposed and the application of the subband Volterra series is used in this paper. Firstly, the subband Volterra series is calculated from the input and output sequences of the circuit under test (CUT). Then the fractional correlation functions between the fault-free case and the incipient faulty cases of the CUT are derived. Using the feature vectors extracted from the fractional correlation functions, the hidden Markov model (HMM) is trained. Finally, the well-trained HMM is used to accomplish the incipient fault diagnosis. The simulations illustrate the proposed method and show its effectiveness in the incipient fault recognition capability.

Open access

Anthony To-Ming Lau and Yong Zhang

Abstract

It has been a long-standing problem posed by the first author in a conference in Marseille in 1990 to characterize semitopological semigroups which have common fixed point property when acting on a nonempty weak* compact convex subset of a dual Banach space as weak* continuous and norm nonexpansive mappings. Our investigation in the paper centers around this problem. Our main results rely on the well-known Ky Fan’s inequality for convex functions.

Open access

Zhang Zhiyang, Ma Yong, Jiang Jin, Liu Weixing and Ma Qingwei

Abstract

Vertical-axial tidal current turbine is the key for the energy converter, which has the advantages of simple structure, adaptability to flow and uncomplex convection device. It has become the hot point for research and application recently. At present, the study on the hydrodynamic performance of vertical-axial tidal current turbine is almost on 2-D numerical simulation, without the consideration of 3-D effect. CFD (Computational Fluid Dynamics) method and blade optimal control technique are used to improve accuracy in the prediction of tidal current turbine hydrodynamic performance. Numerical simulation of vertical-axial tidal current turbine is validated. Fixed and variable deflection angle turbine are comparatively studied to analysis the influence of 3-D effect and the character of fluid field and pressure field. The method, put the plate on the end of blade, of reduce the energy loss caused by 3-D effect is proposed. The 3-D CFD numerical model of vertical-axial tidal current turbine hydrodynamic performance in this study may provide theoretical, methodical and technical reference for the optimal design of turbine.

Open access

Zheshu Ma, Hua Chen and Yong Zhang

Abstract

The increase of ship’s energy utilization efficiency and the reduction of greenhouse gas emissions have been high lightened in recent years and have become an increasingly important subject for ship designers and owners. The International Maritime Organization (IMO) is seeking measures to reduce the CO2 emissions from ships, and their proposed energy efficiency design index (EEDI) and energy efficiency operational indicator (EEOI) aim at ensuring that future vessels will be more efficient. Waste heat recovery can be employed not only to improve energy utilization efficiency but also to reduce greenhouse gas emissions. In this paper, a typical conceptual large container ship employing a low speed marine diesel engine as the main propulsion machinery is introduced and three possible types of waste heat recovery systems are designed. To calculate the EEDI and EEOI of the given large container ship, two software packages are developed. From the viewpoint of operation and maintenance, lowering the ship speed and improving container load rate can greatly reduce EEOI and further reduce total fuel consumption. Although the large container ship itself can reach the IMO requirements of EEDI at the first stage with a reduction factor 10% under the reference line value, the proposed waste heat recovery systems can improve the ship EEDI reduction factor to 20% under the reference line value.

Open access

Zhang Zhi-yong, Li Ming-xu, Yu Yong-wu and Zhou Chun-hua

Abstract

Background: At present, patients with end-stage renal failure (ESRD) face the question of how to achieve adequate dialysis to maintain their survival with the best quality of life as long as possible. Therefore, the choice of suitable dialysis methods and dialysis dose is important.

Objective: To find suitable dialysis methods and an appropriate dialysis dose for patients with ESRD.

Methods: Our research compares the long-term clinical effects between the patients undergoing continuous ambulatory peritoneal dialysis (CAPD), daytime ambulatory peritoneal dialysis (DAPD), and hemodialysis (HD). Thirty-two patients subjected to peritoneal dialysis were selected and divided into group A (n = 16) and group B (n = 16), group A was treated by using the traditional CAPD pattern; group B was treated by using DAPD. Forty-six patients of renal failure at final stage were divided into group A (n = 23) and group B (n = 23), group A was treated by using a HD method, group B was treated by using a DAPD method.

Results: When the same dialysis dose was applied, the patients with long-term DAPD treatment can obtain satisfactory clinical therapeutic efficacy for the period of maintenance dialysis, thoroughness of dialysis, maintenance of nutritional status, blood pressure regulation, reduction in incidence rate of peritoneal infection, maintenance of relatively high activity in daily life and alleviation in depression, comparable to patients treated with traditional CAPD or HD methods.

Conclusion: The long-term clinical effects of DAPD are comparable to CAPD or HD.

Open access

Yong Guo, Xizheng Zhang, Chunqiu Zhang, Ruixin Li, Qiangcheng Zeng, Chun Guo and Yanjun Zhang

Abstract

Background: Mesenchymal stem cells (MSCs) known to be sensitive to mechanical stimulus. This type of stimulus plays a role in cellular differentiation, so that it might affect MSCs differentiation toward cardiomyocytes.

Objectives: Investigate the effect of mechanical stimulus on MSCs differentiation toward cardiomyocytes.

Methods: The adipose tissue-derived MSCs were induced to differentiate with 5-azacytidine, and stimulated by one Hz mechanical stretching up to 8%. After 10 days, the cell’s cardiac markers and cardiogenesis-related genes were detected by immumohistochemistrical staining and reverse transcriptase-polymerase chain reaction, and the cell’s ATPase activity was detected.

Results: The cyclic mechanical stretching enhanced the expression of cardiogenesis-related genes and cardiac markers, and stimulated the activity of Na+-K+-ATPase and Ca2+-ATPase in the MSCs treated with 5-azacytidine. Without 5-azacytidine pre-treatment, cyclic mechanical stretch alone has little effect.

Conclusion: Mechanical stretch combined with 5-azacytidine treatment could accelerate MSCs differentiation toward cardiomyocytes.

Open access

Jia Tian-Rang, Zhang Zi-Min, Tang Chun-An and Zhang Yong-Jun

Field test and laboratory analog model test on the stress-relief effects of protective layer extraction are time-consuming and laborious. In this paper, on the basis of full consideration of rock heterogeinity and in combination with gas geology at Pingdingshan Mine 5, a numerical model was estalished with the gas-solid coupling rock failure process analysis system RFPA-Gas to simulate the stress variation law, roof and floor deformation, fracture evolution law, displacement in the protected seam, change in gas permeability and gas migration law during protective layer extraction. The simulation results repoduced stress variations in coal and rock strata, roof and floor deformation and fracture evolution process during protective layer extraction. The movement of rock strata were characterized by upper three zones and lower two zones: caving zone, fracture zone and bending subsidence zone in the vertical direction in the overlying strata; floor deformation and failure zone and elasto-plastic deformation zone in the vertical direction in the underlying strata. It showed that stress relief occurred in the protected seam, which led to vertical and horizontal displacements, significant increase in gas permeability, gas desorption and migration. Hence, the outburst threat in the protected seam was eliminated. Meanwhile, with comprehensive analysis of variaition of stress state, deformation characteristics and fracture distribution in coal seam and with consideration of changes in gas leakage rate, gas pressure and permeability, according to gas leakage rate, the floor strata of the protecive layer were divided into four leakage zones. They corresponded to four zones with different stress states and fracture development: original leakage zone - slow reducing leakage zone - dramatic increasing leakage zone- steady increasing leakage zone. This classification provides a clear direction for gas control in the protective layer. The simulation results are in good agreement with the stress-relief effects in field.

Open access

Lin Fang, Hai-Bing Zhang, Hua Li, Yong Fu and Guang-Shun Yang

miR-548c-5p inhibits proliferation and migration and promotes apoptosis in CD90+ HepG2 cells

Background. Since the introduction of the theory of tumour stem cells (TSCs), the liver cancer stem cell (LCSC)-like cells have become one of the focuses in the research on liver cancer.

Materials and methods. In this study, CD90+ cells were applied as the possible LCSC-like cells, and the miRNA and gene expression were analyzed in the CD90+ HepG2 cells. The pilot study showed miR-548c-5p exerted potential effect on the CD90+ HepG2 cells and was thereafter applied for the further study. CD90+ HepG2 cells were assigned to miR-548c-5p mimic transfection group and control group. MTT assay was performed to detect the proliferation of CD90+ HepG2 cells. The migration and invasion abilities were examined by wound healing assay and transwell migration assay, respectively. A detection of apoptosis was performed by fluorescence microscopy.

Results. Our results showed that caspase-3 and bcl-2 were down-regulated while caspase-8 was up-regulated in the CD90+ HepG2 cells. Moreover, the miR-548c-5p transfection could down-regulate the expression of β-catenin, Tg737, bcl-2, bcl-XL, and caspase-3, inhibit the proliferation, migration and invasion and promote the apoptosis of the CD90+ HepG2 cells.

Conclusions. Our findings indicate the imbalance between apoptosis and anti-apoptosis in the LCSC-like cells, which influence the biological features of LCSC-like cells. miRNA plays a regulatory role in the LCSC-like cells among which miR-548c-5p might be a suppressor.

Open access

Da-yong Zhang, Song-song Yu, Yanlin Wang and Qian-jin Yue

Abstract

Bohai is a typical marginal oil field in an ice region, where most of the oil and gas platforms are economical. Sea ice is the main factor that affects the safety of oil and gas platforms in Bohai. Due to the complexity of the ice load and ice-induced vibrations, there are large security risks when developing Bohai oil and gas in the winter. It is difficult to ensure the safe production of oil and gas in winter using existing sea ice disaster warning technologies. Based on winter oil and gas production in the Bohai Sea’s Liaodong Bay, a set of suitable sea ice management systems is proposed in this paper. These systems integrate sea ice monitoring, risk assessment and risk prediction technologies. Based on the risk warning system, an ice management model of a Bohai ice platform has been put into practice, which ensures the safe production of the platform in winter.