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Open access

Yongming He, Yuan Wang, Yingwu Chen and Lining Xing

Abstract

Satellite hardware has reached a level of development that enables imaging satellites to realize applications in the area of meteorology and environmental monitoring. As the requirements in terms of feasibility and the actual profit achieved by satellite applications increase, we need to comprehensively consider the actual status, constraints, unpredictable information, and complicated requirements. The management of this complex information and the allocation of satellite resources to realize image acquisition have become essential for enhancing the efficiency of satellite instrumentation. In view of this, we designed a satellite auto mission planning system, which includes two sub-systems: the imaging satellite itself and the ground base, and these systems would then collaborate to process complicated missions: the satellite mainly focuses on mission planning and functions according to actual parameters, whereas the ground base provides auxiliary information, management, and control. Based on the requirements analysis, we have devised the application scenarios, main module, and key techniques. Comparison of the simulation results of the system, confirmed the feasibility and optimization efficiency of the system framework, which also stimulates new thinking for the method of monitoring environment and design of mission planning systems.

Open access

Muyao Zhang, Xing Wei and Zhenfei Wang

Abstract

Hepatocellular carcinoma (HCC) is the sixth most common malignancy worldwide and the third most common cause of death from cancer, after lung and stomach cancer. Hepatitis B virus (HBV) infection is closely related to HCC and is a major cause of HCC. HBV is a lysogenic virus of the hepadnavirus family. Its genome presents a slack, ring-like, double-chain structure, containing four open reading frames. The X region encodes the product HBV X protein (HBx), which is a multifunctional regulatory protein that plays an important role in intracellular signal transduction, viral genome replication and transcription, cell proliferation and apoptosis, cell cycle progression, protein degradation, and genetic stability of hepatocytes. This article summarizes the recent research on the mechanism of promotion of initiation and progression of HCC by HBx protein.

Open access

Sang Jianbing, Xing Sufang, Wang Ling, Wang Jingyuan and Zhou Jing

Abstract

Rubber membranes exhibit a particular nonlinear elastic behaviour known as hyper elasticity. Analysis has been proposed by utilizing the modified strain energy function from Gao’s constitutive model, in order to reveal the mechanical property of rubber membrane containing circular rigid inclusion. Rubber membrane is taken into incompressible materials under axisymmetric stretch, based on finite deformations theory. Stress distribution of different constitutive parameters has been analyzed by deducing the basic governing equation. The effects on membrane deformation by different parameters and the failure reasons of rubber membrane have been discussed, which provides reasonable reference for the design of rubber membrane.

Open access

Feng Li, Hao Qin, Xing Zhi, Wang Zhenfei and Wang Ziwei

Abstract

Objective

The objective of this study was to discuss the effect of double perfusion cannula accompanied with low negative pressure drainage in the treatment of complexity of abdominopelvic and perineal infections.

Methods

The technology of the double perfusion cannula accompanied with low negative pressure drainage was used to treat complexity of abdominopelvic and perineal infections.

Results

Double perfusion cannula accompanied with low negative pressure drainage can be applied to the treatment of complexity of abdominopelvic and perineal infections. It has an obvious effect on infection control and reduces recovery time.

Conclusion

Double perfusion cannula accompanied with low negative pressure drainage has a good effect on complexity of abdominopelvic and perineal infections; it can be used in wider surgical fields to prevent infections.

Open access

Liang Guo, Jun Guan, Mingqing Xing, Zhengzhong Wang, Fangjie Hou, Conghui Xing and Yuping Lei

Abstract

Background: Doxorubicin has been widely used to treat many cancers. It also induces cumulative and delayed cardiomyopathy. New biological markers to predict cardiac toxicity is needed.

Objectives: We identified novel markers and potential therapeutic targets of doxorubicin (DOX)-induced cardiac toxicity by proteomics approach.

Methods: The protein profiling of H9c2 cells in response to DOX at an apoptosis-induced concentration (0.5⃞M) were compared by two-dimensional electrophoresis (2-DE) and mass spectrometry.

Results: A total of nine differently expressed proteins were identified including six up-regulated and three downregulated proteins. We further confirmed the expression of two down-regulated proteins, prohibitin and endoplasmic reticulum protein ERp29 (ERp29), decreased in response to DOX induction by Western-blot, and over-expression of ERp29 also partially recovered the MTT reduction.

Conclusion: We first identified ERp29 and prohibitin as novel markers for DOX toxicity, and ERp29 might be a candidate target to develop novel therapeutic strategies to alleviate adverse effects of doxorubicin-based chemotherapies.

Open access

Sanxiu Wang, Kexin Xing and Zhengchu Wang

Abstract

In this paper an adaptive fuzzy H∞ robust tracking control scheme is developed for a class of uncertain nonlinear Multi-Input and Multi-Output (MIMO) systems. Firstly, fuzzy logic systems are introduced to approximate the unknown nonlinear function of the system by an adaptive algorithm. Next, a H∞ robust compensator controller is employed to eliminate the effect of the approximation error and external disturbances. Consequently, a fuzzy adaptive robust controller is proposed, such that the tracking error of the resulting closed-loop system converges to zero and the tracking robustness performance can be guaranteed. The simulation results performed on a two-link robotic manipulator demonstrate the validity of the proposed control scheme.

Open access

Bin Zhang, Wen-hui Lun, Xing-wang Li, Qi Wang, Jun Cheng and Yu Mao

Abstract

Objective To construct prokaryotic expression vector of CFP-10 gene, and obtain recombinant protein, and the recombinant CFP-10 protein was taken as stimulus to detect specific T cell responses, to set up a method to faciliate to detect potential TB infection in China.

Methods CFP-10 was cloned into inducible prokaryotic expression vector pET-32a (+) and transfected into E. coli BL21 (DE3). After IPTG induction, the product were verified with sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and Western blot hybridization were carried out to verify the antigenicity; the recombinant CFP-10 protein was taken as stimulus to detect specific T cell responses in HIV (+) persons with or without clinical manifestation of TB diseases, and HIV (-) controls with or without TB diseases.

Results The CFP-10 recombinant protein exsited in the form of inclusion body and accounted for 94% in total bacterial protein of E. coli and the molecular weight is 31 kD; Western blot confirmed the recombinant proteins had high antigenicity; our in-house ELISpot-IFN-γ assay with recombinant antigen derived from CFP-10 proteins showed significant higher frequencies in TB patients with or without HIV infection than that in the healthy controls and only HIV (+) group.

Conclusions The recombinant CFP-10 genes can be expressed successfully in prokaryotic expression system of E. coli and recombinant proteins with high antigenicity were obtained, which will set foundation for further study on their immunogenicity and bioinformatics. Our results proved that it is indeed true that some HIV positive patient have high frequencies of TB specific T cell responses, which maybe a clue to find latent TB infection in this population.

Open access

Y. J. Wang, C. F. Gao, H. P. Song and S. C. Xing

Abstract

The half elliptical hole with an edge crack in a thermopiezoelectric material is studied by using the complex variable method. First, the mapping function which maps the outside of the elliptical hole and the crack in the right half plane into the outside of a circular hole in a full plane is given by the method of conformal mapping. Then, the complex potential functions and the field intensity factors (FIF) are presented according to the boundary conditions, respectively. Some useful results can be found by numerical analysis: 1) The influence of the heat flux on FIF depends on the model of the crack; 2) The shape and the size of the hole possess a significant effect on the field distribution at the crack tip.