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Open access

Jing Luo, Can Sun and Wei Sun

Abstract

Background: Only a few cases of Leiomyomatoid angiomatous neuroendocrine tumor (LANT) have been reported in the literature. Our case adds clinical, pathological, and immunohistochemical features.

Objective: To investigate the clinicopathological characteristics of LANT.

Material and Method: One case of LANT of the myometrium was reported in a review of literature. The morphological and immunohistochemical features were analyzed.

Results: In the course of an annual health examination of a 40-year-old woman, ultrasound results revealed a mass in the myometrium, which was clinically diagnosed as uterine leiomyoma. The patient underwent hysterectomy. Histological examination demonstrated that the tumor was composed of prominent vasculature and cellular stromal around vessels. Mitotic activity was absent. Both vascular and stromal cells showed diffusely expressed CD56 and chromogranin A. Stromal cells also expressed actin, SMA, and desmin, but not CK or HMB45. The pathological diagnosis was LANT of the myometrium. Follow up reported no evidence of recurrence three months after surgery.

Conclusion: LANT is a possible new disease entity. LANT is a dimorphic tumor consisting of smooth muscle and neurosecretory phenotype cells surrounding intratumoral vessels. Surgery may be the best treatment, resulting in good prognosis.

Open access

Chen Wang, Guidong Yu, Wei Sun and Jinde Cao

Abstract

The adjacency matrix of a graph is a matrix which represents adjacent relation between the vertices of the graph. Its minimum eigenvalue is defined as the least eigenvalue of the graph. Let Gn be the set of the graphs of order n, whose complements are connected and have pendent paths. This paper investigates the least eigenvalue of the graphs and characterizes the unique graph which has the minimum least eigenvalue in Gn.

Open access

Ninga Sun, Ying-chaoa Zhang, Wei-guoa Zhang, En-lua Cheng and Yun-ping

Abstract

In order to effectively solve condensation and icing problems of radiosonde in low-temperature environment at high altitude, humidity sensor heated automatic alternately to remove pollution and improve the measurement accuracy. Heat experiments obtained the curve of rising temperature and responsible time on heated twin humidity sensor in normal temperature and pressure, by expanded responsible curve to obtain heated model of twin heated humidity sensor and by the analysis of heating model, use DMC and PID control for heating respectively. Simulation results show that the DMC control meets the practical requirements of measure at high altitude.

Open access

Xue Meng, Yue Sun, Hong-yan Gu, Hong-shan Wei and Xing-wang Li

Abstract

Objective To clone, express and purify C12orf49 recombinant protein. To prepare rabbit anti-C12orf49 protein polyclonal antibody in order to further elucidate its biological function.

Methods PCR was used to amplify the gene C12orf49 in vitro. pET-32a (+)-C12orf49, the recombinant protein prokaryotic expression vector, was transformed into E. coli. IPTG was used as the inductive agent to obtain C12orf49 recombinant protein, and the recombinant protein was analyzed with sodium dodecyl sulfatepolyacrylamide gel electrophoresis (SDS-PAGE) and Western blot. Specific polyclonal antibody was derived from rabbits that immunized by recombinant protein. ELISA and Western blot were used to test its titer and specificity, respectively. MTT cell proliferation experiment was carried out to observe effect of the protein on proliferation of HepG2 cells.

Results The C12orf49 recombinant protein was expressed in a large quantity. Data of ELISA indicated that the titer of polyclonal antibody was higher than 1:1 280 000. And the antibody also had a good specificity, confirmed by Western blot. C12orf49 recombinant protein may had a advanced effect on the proliferation of HepG2 cells.

Conclusions Using C12orf49 recombinant protein, we can obtain the polyclonal antibody with great titer and good specificity. Human novel gene C12orf49 encoded protein could promote the proliferation of HepG2 cells.

Open access

Q. Liang, W. Wu, D. Zhang, B. Wei, W. Sun, Y. Wang and Y. Ge

Abstract

Roughness, which can represent the trade-off between manufacturing cost and performance of mechanical components, is a critical predictor of cracks, corrosion and fatigue damage. In order to measure polished or super-finished surfaces, a novel touch probe based on three-component force sensor for characterizing and quantifying surface roughness is proposed by using silicon micromachining technology. The sensor design is based on a cross-beam structure, which ensures that the system possesses high sensitivity and low coupling. The results show that the proposed sensor possesses high sensitivity, low coupling error, and temperature compensation function. The proposed system can be used to investigate micromechanical structures with nanometer accuracy.

Open access

Shiyong Li, Wei Sun, Cheng-Guo E and Lina Shi

Abstract

Peer-to-peer (P2P) networks offer a cost-effective and easily deployable framework for sharing content. However, P2P file-sharing applications face a fundamental problem of unfairness. Pricing is regarded as an effective way to provide incentives to peers to cooperate. In this paper we propose a pricing scheme to achieve reasonable resource allocation in P2P file-sharing networks, and give an interpretation for the utility maximization problem and its sub-problems from an economic point of view. We also deduce the exact expression of optimal resource allocation for each peer, and confirm it with both simulation and optimization software. In order to realize the optimum in a decentralized architecture, we present a novel price-based algorithm and discuss its stability based on Lyapunov stability theory. Simulation results confirm that the proposed algorithm can attain an optimum within reasonable convergence times.

Open access

Likai Zhuang, Ming Bai, Wei Zhou, Yongguo Yu, Jian Wang, Qihua Fu and Jie Sun

Summary

Background: This study aimed to investigate the significance of MAMLD1 mutations in the incidence of hypospa-dias in a Chinese population.

Methods: The experimental group consisted of 150 domestic children with hypospadias, aged 0.5 to six years and living in different provinces. A total of 120 normal children, aged two to six years, served as the control group. DNA was extracted for the direct sequencing of MAMLD1 genes.

Results: Twelve cases (8.0%) of the missense mutation p.N589S were found in the experimental group, whereas four cases (3.0%) of the same mutation were found in the control group. No significant difference was observed in the mutation rate between the two groups (P>0.05). Four cases (2.7%) had a new missense mutation p.P567S in the experimental group, and three cases (2.5%) possessed the same mutation in the control group. No significant difference was observed between the two groups (P>0.05).

Conclusions: In this study, the importance of repeated experiments in mutation-related studies was confirmed, which revealed the difference in predisposing genes among different populations. Although the mutation of the MAMLD1 gene had no apparent connection with the incidence of hypospadias in a Chinese population, a new mutation site of the MAMLD1 gene was discovered, which could provide new research topics for future studies.

Open access

Chuan-Zhen Zhao, Tong Wei, Xiao-Dong Sun, Sha-Sha Wang and Ke-Qing Lu

Abstract

A model is developed to describe the pressure dependence of the band gap energy for the dilute nitride GaNxAs1–x. It is found that the sublinear pressure dependence of E is due to the coupling interaction between E+ and E. We have also found that GaNxAs1−x needs much larger pressure than GaAs to realize the transition from direct to indirect band gap. It is due to two factors. One is the coupling interaction between the E+ and E. The other is that the energy difference between the X conduction band minimum (CBM) and the G CBM in GaNxAs1−x is larger than that in GaAs. In addition, we explain the phenomenon that the energy difference between the X CBM and the G CBM in GaNxAs1−x is larger than that in GaAs. It is due to the impurity-host interaction.

Open access

Hong-Yan Sun, Xin Kong, Wei Sen, Zhong-Zhou Yi, Bao-Sen Wang and Gui-Yang Liu

Abstract

Effect of different Sn contents on combustion synthesis of Ti2SnC was studied using elemental Ti, Sn, C and TiC powders as raw materials in the Ti-Sn-C and Ti-Sn-C-TiC system, in which the molar ratio of Ti/C was set as 2:1. The reaction mechanism for the formation of Ti2SnC was also investigated. The results showed that the amount of Ti2SnC in combustion products firstly increased with increasing of Sn content (0.6 to 0.8 mol), and then decreased with further increasing of Sn content (1.0 to 1.2 mol). Upon addition of 15 % TiC instead of Ti and C, the optimum addition of Sn decreased to 0.7 mol and a higher purity of Ti2SnC was obtained. The Ti2SnC powders were characterized by scanning electron microscopy (SEM) and X-ray diffraction (XRD).