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Open access

Qing-wei Gao and De-sheng Yuan

Abstract

Objective To observe the clinical manifestations and assess direct antiviral effect for patients with occult hepatitis B in China.

Methods The study includes 15 patients with occult hepatitis B and their medical history, family history, first-diagnosis time, confirmed-diagnosis time, laboratory report, anti-viral therapy and outcomes were analyzed.

Results The average age of the patients is 38.67-year old (6 males and 9 females), 2 with acute hepatitis B (2/15, 13.3%), 13 with no hepatitis history (13/15, 86.6%), 8 with family history (8/15, 53.3%), 6 with no family history (6/15, 40%), 1 with unknown family history (1/15, 6.6%). Eight patients were treated with entecavir (0.5 mg/day, taken orally), with effective results and steady conditions; 3 patients were treated with lamivudine (0.1 g/day, taken orally), 2 of them were prescribed to take adefovir dipivoxil additionally due to drug-resistance, the other one was treated with lamivudine continuously without drug-resistance; 4 cases refused anti-viral therapy. One patient’s condition remained steady, 1 patient died of cirrhosis with portal hypertension and liver failure 5 years after firstdiagnosis, 1 patient progressed to hepatocellular carcinoma and accepted surgery operation treatment 5 years after first-diagnosis, the other 1 patient progressed to compensatory cirrhosis 2 years after first-diagnosis and is steady from then, which indicates that occult chronic hepatitis B can progress to cirrhosis and hepatocellular carcinoma without therapy in time.

Conclusions The clinical characteristics of 15 cases with occult chronic hepatitis B showed that these patients with short latency, younger age when being-struck, and light damage to liver function. The efficacy and drugresistance of nucleos(t)ide-analogue (entecavir, lamivudine, adefovir dipivoxil) in treatment of patients with occult chronic hepatitis B are similar to chronic hepatitis B.

Open access

Wei Gao and Mohammad Reza Farahani

Abstract

In computational chemistry, the molecular structures are modelled as graphs which are called the molecular graphs. In these graphs, each vertex represents an atom and each edge denotes covalent bound between atoms. It is shown that the topological indices defined on the molecular graphs can reflect the chemical characteristics of chemical compounds and drugs. In this paper, we report several degree based indices of some widely used chemical molecular structures by means of edge dividing technology.

Open access

Wenjuan Li, Wei Liu, Xu Xu and Zhijun Gao

Abstract

Under the new normal of China’s economy, the competition among the port enterprises is not only the competition of the core competence of the port, the port industry chain or the port supply chain, but also the competition of the port service ecosystem. In this paper, the concept and characteristics of the port service ecosystem is discussed, a hierarchical model of the port service ecosystem is constructed. As an extended logistic model, Lotka-Volterra model is applied to study the competitive co-evolution and mutually beneficial co-evolution of enterprises in the port service ecosystem. This paper simulates the co-evolution of enterprises in the port service ecosystem by using MATLAB programming. The simulation results show that the breadth of the niche of the enterprises is changing with the change of the competition coefficient and the coefficient of mutual benefit in the port service ecosystem. Based on that, some proposals are put forward to ensure the healthy and orderly development of the port service ecosystem.

Open access

Yun Gao, Mohammad Reza Farahani and Wei Gao

Abstract

In this article, we propose an ontology learning algorithm for ontology similarity measure and ontology mapping in view of distance function learning techniques. Using the distance computation formulation, all the pairs of ontology vertices are mapped into real numbers which express the distance of their corresponding vectors. The more distance between two vertices, the smaller similarity between their corresponding concepts. The stabilities of our learning algorithm are defined and several bounds are yielded via stability assumptions. The simulation experimental conclusions show that the new proposed ontology algorithm has high efficiency and accuracy in ontology similarity measure and ontology mapping in certain engineering applications.

Open access

Abdul Qudair Baig, Muhammad Naeem and Wei Gao

Abstract

Let G be a connected graph with vertex set V(G) and edge set E(G). Recently, the Revan vertex degree concept is defined in Chemical Graph Theory. The first and second Revan indices of G are defined as R 1(G) = uvE[rG(u) + rG(v)] and R 2(G) = uvE[rG(u)rG(v)], where uv means that the vertex u and edge v are adjacent in G. The first and second hyper-Revan indices of G are defined as HR 1(G) = uvE[rG(u) + rG(v)]2 and HR 2(G) = uvE[rG(u)rG(v)]2. In this paper, we compute the first and second kind of Revan and hyper-Revan indices for the octahedral and icosahedral networks.

Open access

Qing-wei Gao, Han-fa Zou, Liang Kong and De-sheng Yuan

Abstract

Objective To configure an immunoabsorption column for hepatitis B virus.

Methods Being activated by epichlorohydrin, the human antibody HBsAb-IgG was bound to the carrier of agarose gel. The configuration process was as follows: the synthesis of epoxide matrix, the synthesis and activation of amino matrix, the synthesis of aldehydic matrix, the synthesis of immunoabsorption matrix, the end capping and reduction of unbound aldehydic, the blocking of unbound mass and the filling of the column.

Results The bound rate of activated agarose gel and antibody HBsAb-IgG is 85.07%. By plasma adsorption experiment, it is revealed that the immunoabsorption column can absorb and eliminate 58.97% of HBsAg and 53.1% of hepatitis B virus particles in extracorporeal plasma.

Conclusions The immunoabsorption column for hepatitis B virus can absorb and eliminate HBsAg and hepatitis B virus particles in extracorporeal plasma.

Open access

Xue-Mei Xiong, Bo-Wen Zhao, Chun-Hong Nie, Wei-Min Wang and Ze-Xia Gao

Abstract

TThe length-weight relationships (LWRs) were determined for five freshwater fish species collected from Liangzi Lake, the Xi River and Longxi River in China, including Megalobrama amblycephala, Megalobrama skolkovii, Megalobrama pellegrini and Megalobrama terminalis belonging to the genus Megalobrama, as well as white Amur bream (Parabramis pekinensis) of the genus Parabramis. Three of these five species had no previous LWR estimates in the FishBase. The LWRs of hybrids from Megalobrama amblycephala ♀ × Parabramis pekinensis ♂ and Megalobrama amblycephala ♀ × Megalobrama terminalis ♂ were also reported for the first time.

Open access

Jing-Yi Cheng, Yi-Dong Zhang, Liang Cheng, Ming Ji, Wei Gu and Lin-Sheng Gao

Abstract

According to complex geological conditions of working face E1108 in Xin-ji mine #2, loading and running characteristic of hydraulic support, influence of depression angle on mining pressure behaviors, as well as relation between advancing speed and the support loading were measured and analyzed. The results indicate that depression angle is inversely proportional to support resistance, in other words, larger depression angle area coincides with lower support resistance area. Moreover, support resistance is generally high when working face advancing speed is slow. Technologies for controlling hydraulic support stability such as improving advancing speed properly, controlling mining height and increasing support resistance are put forward based on research.

Open access

B. Basavanagoud, Wei Gao, Shreekant Patil, Veena R. Desai, Keerthi G. Mirajkar and B Pooja

Abstract

For a (molecular) graph, the first Zagreb index is equal to the sum of squares of the degrees of vertices, and the F-index is equal to the sum of cubes of the degrees of vertices. In this paper, we introduce sixty four new operations on graphs and study the first Zagreb index and F-index of the resulting graphs.

Open access

Jiang Xiao, Yan-mei Li, Ying-xiu Huang, Wen Zhang, Wen-jing Su, Wei Zhang, Ning Han, Di Yang, Xin Li, Gui-ju Gao and Hong-xin Zhao

Abstract

Objective The aim of the study was to evaluate the characteristics of HIV drug-genotypic resistance among patients taking first-line ARV regimens using polymerase chain reaction and sequencing, and guide to design optimal ARV regimens for these patients.

Methods HIV reverse transcriptase-encoded gene was amplified with RT-PCR and amplified PCR products were aligned and comparatively analyzed with HIV resistance database to find drug-resistance mutations.

Results Twenty-eight PCR products were amplified and sequenced successfully in 30 serum samples of recruited HIV-infected patients with virologic failure. The resistance rate was 96%, mutations in NRT region were found in 26 patients (93%), while mutations in NNRT region were found in 27 patients (96%). M184V was the most common mutation (86%), K65R was selected in 14% of recruited individuals and TAMs occurred in 50% of patients, which resulted in resistance to NRTIs. Y181C and V179D were the most common mutations in NNRTIs and prevalence was 43% (12/28) and 36% (10/28), respectively, which resulted in cross-resistance to NNRTIs due to low-genetic barrier.

Conclusions Virologic failure may occur in long-term administration of first-line ARV regimens, and drugresistance mutations can be found in these patients, which resulted in resistance to first-line ARV regimens. We emphasized that HIV viral load assay and resistance assay were important tools to guide healthcare workers to design an optimal second-line ARV regimens for HAART-experienced individuals with virologic failure.