Acne vulgaris is a common skin disease, which affects individuals of all races and ages. In Caucasians, almost 85% of individuals between 12 and 25 years, as well as 25% of adults, are affected with some forms of acne. The pathophysiology of acne is multifactorial, and thus, the treatment must cover all the possible causes of acne. For this reason, acne therapy is mostly a combination therapy, with the main goal to achieve clinical improvement, without scarring and residuals, as much as possible. The treatment should be planned individually, depending on the clinical appearance, severity and psychological profile of the patient. The treatment usually takes time and requires dedication and patience of both the patient and the physician.