I reported a case of a seventy-five-year-old woman with a backache and pain in left femur. Magnetic resonance imaging (MRI) of back, pelvis and hips showed bone marrow lesion suggesting bone metastasis. The patient was admitted to nuclear medicine department of Krasnoyarsk Regional Clinical Oncology Center. Single-photon emission computed tomography combined with computed tomography (SPECT/CT) of the skeletal system together with several laboratory tests (alkaline phosphatase, calcium, phosphorus), provided grounds for the diagnosis of Paget’s disease. The patient was qualified for treatment to the Rheumatologist.