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  • Author: Umar Farooq x
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Abstract

With the increased number of multi-drug formulations, there is a need to develop new methods for simultaneous determinations of drugs. A precise, accurate and reliable liquid chromatographic method was developed for simultaneous determination of paracetamol, thiamine, and pyridoxal phosphate in pharmaceutical formulations. Separation of analytes was carried out with an Agilent Poroshell C18 column. A mixture of ammonium phosphate buffer (pH = 3.0), acetonitrile and methanol in the ratio of 86:7:7 (V/V/V) was used as the mobile phase pumped at a flow rate of 1.8 mL min−1. Detection of all three components, impurities and degradation products was performed at the selected wavelength of 270 nm. The developed method was validated in terms of linearity, specificity, precision, accuracy, LOD and LOQ as per ICH guidelines. Linearity of the developed method was found in the range 17.5–30 µg mL−1 for thiamine, 35–60 µg mL−1 for pyridoxal phosphate and 87.5–150 µg mL−1 for paracetamol. The coefficient of determination was ≥ 0.9981 for all three analytes. The proposed HPLC method was found to be simple and reliable for the routine simultaneous analysis of paracetamol, thiamine and pyridoxal phosphate in tablet formulations. Complete separation of analytes in the presence of degradation products indicated selectivity of the method.

Abstract

The Gwal mélange is mapped on a large scale and is divided into the lithological units such as ultramafic, mafic, volcanic, volcanoclastic rocks, pelagic sediments and ophicarbonates. Petrographically, the mapped rocks are classified as harzburgite, dunite, wehrlite, serpentinite, gabbro, basalt, and andesite. These rocks are quite deformed and altered into the secondary minerals. Harzburgite is a layered mantle peridotite consists of olivine and orthopyroxene while dunite lacks the presence of any pyroxene. Serpentinite is the secondary product after peridotite is the product of post magmatic stages. The mesh structure is usually observed when olivine is completely altered to serpentine. The volcanic rocks are structurally sheeted and pillow type while the volcanoclastic rocks are essentially hyaloclastites associated with pelagic sediments. The Ophicarbonate is composed of serpentinite fragments and carbonate minerals, most probably calcite. Minor to trace amounts of opaque minerals are also present in association with major components. The gabbros may be a fragment of the main crustal rocks and have been formed in a magma chamber by fraction crystallization. The origin of ophicarbonate may be due to gas seeps originated by mantle or as the surficial process where ultramafic rocks and carbonates are mixed through processes of gravity, tectonic crushing and sedimentary reworking. The Gwal mélange may the southern extension of Bagh Complex found beneath the Muslim Bagh Ophiolite. The mantle peridotite of the mélange is much like that of the Khanozai peridotite and may represent its detached blocks. Volcanic and volcanoclastic rocks may be the representatives of the uppermost part of ophiolite crust which might have trimmed off from subducting slab and are, now, part of the Gwal accretionary wedge. The mélange may have tectonically emplacement over the Indian platform sediments along with overlying the ophiolite sheet during the Late Cretaceous.

Abstract

Antimony is a promising material for the fabrication of photodetectors. This study deals with the growth of a photosensitive thin film by the physical vapor deposition (PVD) of antimony onto mica surface in a furnace tube. The geometry of the grown structures was studied via scanning electron microscopy (SEM), X-ray diffraction (XRD), energy-dispersive X-ray spectroscopy (EDX) and elemental diffraction analysis. XRD peaks of the antimony film grown on mica mostly matched with JCPDF Card. The formation of rhombohedral crystal structures in the film was further confirmed by SEM micrographs and chemical composition analysis. The Hall measurements revealed good electrical conductivity of the film with bulk carrier concentration of the order of 1022 Ω·cm-3 and mobility of 9.034 cm2/Vs. The grown film was successfully tested for radiation detection. The photoresponse of the film was evaluated using its current-voltage characteristics. These investigations revealed that the photosensitivity of the antimony film was 20 times higher than that of crystalline germanium.