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Wang Tong, Wu Jiyi, Xu He, Zhu Jinghua and Charles Munyabugingo

In the routing protocol for wireless sensor network, the cluster size is generally fixed in clustering routing algorithm for wireless sensor network, which can easily lead to the “hot spot” problem. Furthermore, the majority of routing algorithms barely consider the problem of long distance communication between adjacent cluster heads that brings high energy consumption. Therefore, this paper proposes a new cross unequal clustering routing algorithm based on the EEUC algorithm. In order to solve the defects of EEUC algorithm, this algorithm calculating of competition radius takes the node’s position and node’s remaining energy into account to make the load of cluster heads more balanced. At the same time, cluster adjacent node is applied to transport data and reduce the energy-loss of cluster heads. Simulation experiments show that, compared with LEACH and EEUC, the proposed algorithm can effectively reduce the energy-loss of cluster heads and balance the energy consumption among all nodes in the network and improve the network lifetime

Open access

Tong Wu, Guanhua Wang, Caihong Shi, Jinghan Li, Na Zhao, Zihao Dong, Weisan Pan and Xiangrong Zhang


The purpose of this study was to prepare a mosapride citrate-resin (Amberlite® IRP 88) complex and orally fast-disintegrating tablets of the resin complex. The resinate complex of mosapride-Amberlite® IRP 88, mass ratio 2:1, was prepared in an ethanol-water solution. The effects of alcohol concentration, temperature, and pH of the solution on complex formation were evaluated. The complex physicochemical properties were characterized by differential scanning calorimetry, X-ray diffraction and scanning electron microscopy. Orally disintegrating tablets were prepared by direct compression and were optimized using the response surface method. Optimized orally fast-disintegrating tablets disintegrated within 18 s. The pH dependence of mosapride release from the tablet decreased drug dissolution in simulated saliva, whereas it promptly released in the pH 1.0 solution. The data reported herein clearly demonstrate that tablets containing the mosapride-Amberlite® IRP 88 complex for oral disintegration could be particularly useful for patients with swallowing difficulties.

Open access

Shengdong Zhu, Pei Yu, Mingke Lei, Yanjie Tong, Lu Zheng, Rui Zhang, Jun Ji, Qiming Chen and Yuanxin Wu

Ionic liquid (IL) pretreatment of lignocellulosic materials has provided a new technical tool to improve lignocellulosic ethanol production. To evaluate the influence of the residual IL in the fermentable sugars from enzymatic hydrolysis of IL pretreatment of lignocellulosic materials on the subsequent ethanol fermentation, the toxicity of the IL 1-butyl-3-methylimidazolium chloride ([BMIM]Cl) to Saccharomyces cerevisiae AY93161 was investigated. Firstly, the morphological structure, budding and metabolic activity of Saccharomyces cerevisiae AY93161 at different [BMIM]Cl concentrations were observed under an optical microscope. The results show that its single cell morphology remained unchanged at all [BMIM]Cl concentrations, but its reproduction rate by budding and its metabolic activity decreased with the [BMIM]Cl concentration increasing. The half effective concentration (EC50) and the half inhibition concentration (IC50) of [BMIM]Cl to Saccharomyces cerevisiae AY93161 were then measured using solid and liquid suspension culture and their value were 0.53 and 0.39 g.L-1 respectively. Finally, the influence of [BMIM]Cl on ethanol production was investigated. The results indicate that the [BMIM]Cl inhibited the growth and ethanol production of Saccharomyces cerevisiae AY93161. This toxicity study provides useful basic data for further development in lignocellulosic ethanol production by using IL technology and it also enriches the IL toxicity data.