The present study represents a social and geographical analysis of the spatial distribution of pharmacies in Craiova city using GIS methods. This study aims to present the evolution in the pharmacies’ number, location, density and accessibility to the population of Craiova city on the background of an analysis of European and national legislation concerning the pharmaceutical sector. The paper also outlines the uneven distribution of pharmacies in the city by analysing the ratio between the number of pharmacies and the number of people within a district. Distance and time are considered important, especially when using different transport types. Indicators like density of pharmacies, distribution of population density, and population size in districts were taken into account in this study. Although the GIS-based analysis revealed that accessibility of pharmacies in terms of time and distance and the ratio of population size to number of pharmacies were both good and had increased over the years, the study also indicated residential areas with no pharmacy, and therefore an uneven distribution of pharmaceutical services.