Mihai-Constantin Balaşa, Ştefan Cuculici, Cosmin Panţu, Simona Mihai, Alexis-Daniel Negrea, Mihai-Octavian Zdrafcu, Dorin-Dacian Leţ, Viviana Filip and Ştefan Cristea
Designing orthopedic implants with a long lifespan is essential for improving patients’ quality of life. It is necessary to develop new products with a high degree of personalization for the human body. Physicians and engineers analyzed the geometry and behavior of healthy joints’ motion under specific load conditions as well as the behavior over time and lifetime of orthopedic implants fitted to patients to improve their quality. The paper presents the way in which three-dimensional modeling techniques using specialized software (Catia, SolidWorks) can be combined with reverse engineering techniques (3D scanning) to optimize the design of orthopedic implants. The design of an implant consists of its three-dimensional modeling, as well as simulation of its integration into the human body, in order to analyze its behavior during motion. Therefore, it is necessary not only to 3D model the parts that make up the implant itself, but also to 3D model the bone to which the implant will be fitted. The paper highlights the complementarity of the classic modeling techniques with the reverse engineering techniques, which is necessary because the design of the parts that make up the implant itself can be achieved by specialized software modeling techniques, while the bones, having complex geometries, are better suited to 3D Modeling by scanning.
Mihai Popescu, Dana Tomescu and Simona Olimpia Dima
Early allograft dysfunction (EAD) represents one of the most common and serious complications after liver transplantation (LT). Methods. One hundred sixty-four patients who underwent LT were prospectively included in the present study. Patient demographics, intraoperative blood loss and transfusion were recorded at the time of LT. Lactate levels were recorded during surgery and daily for the first 3 postoperative days. Standard and derived rotational thromboelastometry (ROTEM) parameters were recorded 24 hours after LT. EAD was diagnosed according to Nanashima criteria and post anaesthesia care unit length of stay was recorded. Results. Forty-seven patients (28.6%) developed EAD. Intraoperative blood loss (p = 0.01), packed red blood cells (p = 0.04) and fresh frozen plasma (p = 0.01) transfusion represented intraoperative risk factors for EAD. Lactate levels were significantly higher in patients with EAD at all time points. Patients with EAD demonstrated an increased clot formation time and decreased maximum clot firmness in both intrinsically (p < 0.01) and extrinsically (p < 0.01) activated assay, a decreased thrombin potential index (p < 0.01), area under the curve (p < 0.01) and clot elasticity (p < 0.01) on ROTEM assay. Conclusion. Our results show that both standard and derived ROTEM parameters may indicate early signs of graft failure and can aid in the diagnosis of EAD.
Anca Daniela Pînzaru, Raluca Mihai, Octavia Burcea and Simona Claudia Cambrea
Introduction: In pediatrics, the urinary tract infection is one of the most frequent bacterial infection, representing an important health problem due to its high incidence, wide etiology, asymptomatic evolution, and multiple and sever complications, relapses and sequelae.” Material and Method: We evaluated 45 children, aged between 6 months and 16 years, diagnosed and treated for urinary tract infection at the Clinical Infectious Diseases Hospital, of Constanta County, in a period of 3 years and 6 months. Results: During studied period, between January 2014 and June 2017 from a total of 9343 patients admitted to the Constanta Clinical Infectious Diseases Hospital, we selected 45 children (4.81‰) diagnosed with urinary tract infection. The average age of children with urinary tract infections was 5 years and 5 months. The gender distribution revealed a 2:1 balance in girl’s favor. The most affected group of age was 1-3 years. Fever was the dominating symptom. Urine cultures were positive for 37 cases, meanwhile for eight cases had been negative. The predominant germs are E. coli for female and for male Proteus. We noticed that for E. coli the highest sensitivity is preserved to Ertapenem -15 cases, followed by Ceftriaxone and Ciprofloxacin -10 cases each, and Gentamycin -9 cases. Conclusions: Pediatric urinary tract infection should be considered in every patient under 3 years with unexplained fever.
Mihai Emil Căpîlna, Simona Cristina Rusu, János Bécsi and Mihai Morariu
Introduction: Abdominal radical trachelectomy (ART) for tumors of the uterine cervix can be performed while the pregnancy is ongoing, but the success rates so far are reduced.
Case series presentation: ART was performed in three patients with cervical cancer diagnosed during pregnancy, with a triple aim to offer a radical surgery for cervical cancer, but also to preserve the ongoing pregnancy and fertility. The ART was successful in one patient, and she delivered a healthy baby at term, by cesarean section. The other 2 patients experienced obstetrical complications and lost their pregnancies after ART, but in one of the cases, fertility was preserved.
Conclusions: Radical trachelectomy could be performed as alternative therapy for pregnant women with invasive malignancies of the cervix. This procedure may prevent female patients to lose a much-desired pregnancy, their fertility, as well as their maternity.
The paper referes to the possibility of using neural networks in selecting the “Research-Development” strategy, in the nonconventional technologies field. It presents a selection and the main key elements of the Research and Development (R & D) strategies, applicable in the nonconventional technologies (NT) field and, thus, the specific analytical elements of such a methodology. It also refers to the possibility of using neural networks (“NN”) up to the level of taking managerial decisions regarding the manufacturing processes. Research Objectives: Defining components from the neuron ‘s structure into the organizational systems, in order to select ptime strategies for the organizational management. Expected Results: Transposing the entire methodology in a software.
Mihǎiţǎ Nicolae Ardeleanu, Simona Mihai, Ruxandra Vidu, Emil Mihai Diaconu and Ileana Nicoleta Popescu
A microfluidic device designated for measurement of fluidic flows with different viscosity, necessary within trapping/realising of cells/particles system has been developed. We use a new concept as Microfluidic Pulse Width Modulation (MPWM) for controlling transport of a single cell/particle. The image processing helped the nano-hydraulic volumes/flow rates measurement, through tracking inovative methods with the purpose to build a flow sensor. The device open an unique opportunitie for single cell study with applications in biomedical devices, tools for biochemistry or analytical systems.
Emoke Pall, Raul Alexandru Pop, Simona Ciupe, Mihai Cenariu and Ioan Stefan Groza
Canine mesenchymal stem cells (MSCs) can be defined with self renew potential and specific differentiation capacity. Amiotic membrane represent an important source of MSCs, which can be harvested by minimally invasive methods. The aim of our study was to evaluate the growth characteristics of canine amniotic membrane derived mesenchymal stem cells. The placenta samples were collected after cesarean section from healthy mixed breed dogs. MSCs isolation was performed using enzymatic method. Isolated cells were cultured in propagation medium: Dulbecco’s Modified Eagle’s Medium/F12 (DMEM/F12, Gibco) supplemented with 10% fetal bovine serum (FBS, Gibco) and 1% antibiotic-antimycotic (Sigma-Aldrich). The medium was changed after 4 days. The cell doubling number, cell proliferation capacity, cell doubling time, daily duplication rate and clonogenic efficacy were evaluated. Our study demonstrate the self renew potential of canine amniotic membrane derived mesenchymal stem cells, and can represent a potential source of stem cells for canine regenerative medicine.
Ivona Petre, Aurora Anca Poinescu, Adrian Catangiu and Simona Mihai
With the development of industry have made efforts to improve the performance of braking systems of motor vehicles on public roads. The choice of materials used for coupling brake system involved the development of new materials that meet safety requirements in circulation. During braking of any vehicle, due to the friction created between the disk and pad, temperature rise occurs with negative effects on the process of slowing down the vehicle. Mechanical and thermal stress being put on the brakes is very high. Due to overheating, brake discs and pads may warp or crack, and the material they are made may their change its structure. These defects give rise to vibrations and noise during braking, to reduce the coefficient of friction, reduce the effectiveness of the braking mechanism. This paper proposes a study regarding the thermal stresses effects of brake mechanism on the disc material of a car Dacia Logan. It proposes a theoretical model to calculate the temperature that occurred during the operation of the braking system and experimental analysis on the influence of temperature on the brake disc material.
Irina Camelia Chis, Mihai Socaciu, Remus Moldovan and Simona Clichici
Hyperglycemia and oxidative stress have a major role in the pathogenesis of diabetic vascular complications. In this study, we investigated the efficacy of combining quercetin treatment with moderate exercise training in reversing diabetes-induced oxidative stress and ultrasound modifications in rat carotid arteries. The diabetic Wistar rats were divided into sedentary groups and trained groups. The trained animals went through a regular moderate exercise by swimming (5 weeks). Some non-diabetic and diabetic rats were daily treated with quercetin (30 mg/kg, for 5 weeks). At the end of the study, the imaging evaluation required to assess the effects of diabetes on carotid arteries was performed by micro-ultrasound (MU). The diabetic rats presented atherosclerotic plaques, with an increase in the echogenicity of the carotid artery wall, carotid intima-media thickness (CIMT), and carotid wall thickness, while the diabetic trained rats treated with quercetin presented normal values of these parameters. Malondialde-hyde (MDA) levels, superoxide dismutase (SOD) antioxidant enzyme activity, reduced glutathione (GSH) levels and the reduced (GSH) to oxidized (GSSG) glutathione ratio were determined in the carotid artery tissue. Diabetes caused elevated MDA levels and a decrease in SOD activity, GSH levels and GSH/GSSG ratio in the carotid artery tissue. Treating diabetic rats with quercetin combined with moderate exercise training reversed all these oxidative stress parameters. Our results show that this combination, quercetin and moderate exercise training, can be a good treatment strategy for the vascular complications of diabetes by attenuating hyperglycemia-mediated oxidative stress.
Anca Chiriac, Mihai Mares, Cristian Podoleanu, Cosmin Moldovan and Simona Stolnicu
Introduction: Lately, a new idea has caught the attention of young people of both genders, being debated in consultation rooms, during classes, and especially on social media: is using horse shampoo for human hair wrong or not?
Material and methods: A simple questionnaire about horse shampoo and its use in humans was addressed to 85 students.
Results: Thirty-eight responders were aware of its existence, 27 have tried it and 3 were still using it as a weekly shampoo. All positive responders were young women who declared being completely satisfied by horse shampoo and none of them have reported side effects.
Conclusion: Although it has good reviews, horse shampoo is not available in human pharmacies. As dermatologists, we are still looking for an answer.