Safety and security are considered as basic human needs and fundamental rights. Women, who are among the most vulnerable groups, need more safety and security in neighborhoods. Using a conceptual model, this study explored factors contributing to women's perceptions of safety and security in their neighborhood. In the context of the North Salsabil neighborhood of Tehran (Iran’s capital city), a combination of both qualitative and quantitative methods was applied. The qualitative method was based on the responses of 20 women to semi-structured interview questions; the responses were analyzed applying content analysis. In the quantitative phase, stratified random sampling was used to contact the female participants (N = 200) aged 18 to 65 years old. The measurement instrument used was a questionnaire based on conceptual model indices. The results revealed that women's perception of security in the neighborhood was associated with three main factors: individual characteristics, local community features, and built environment characteristics.