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  • Author: Sebastian Adamczyk x
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Abstract

Background and objectives: To justify the concept of validating conformal versus intensity-modulated approach in the treatment of non-small cell lung cancer (NSCLC). Materials and methods: For 10 patients representative of the spectrum of tumour sizes and locations, two plans were prepared: one with three-dimensional conformal radiation therapy (3DCRT) technique and the other with intensity-modulated radiation therapy (IMRT) technique. Preliminary measurements were performed in static conditions. For each of the field angles considered, the motion kernel was generated to simulate tumour motion trajectories, with the largest amplitude in the cranio-caudal direction of 4, 6, and 8 mm. The measurement results determined the agreement between the planned and measured doses. Results: No statistically significant differences were found between the motion patterns, with the smallest amplitudes for clinical target volume in 3DCRT. For IMRT, the significant differences between 0 mm vs. 6 mm and 0 mm vs. 8 mm amplitudes were found. The motion impact on delivered vs. planned doses had less effect on the oesophagus in 3DCRT compared to that in IMRT. The observed differences were comparable for the heart. Interpretation and conclusions: For maximal amplitudes below 4 mm, the disagreement between planned and delivered doses can be neglected. However, the amplitudes above 5 mm and 7 mm lead to significant changes in IMRT and 3DCRT dose distribution, respectively.

Abstract

To determine the environmental impact, the assessment of the Euro-Pruning project strategy has been carried out in accordance with the checking and scooping list related to Directive 97/11/EC. Additionally, some suggestions and recommendations to prevent/minimize the hazard of accidents or negative interaction on surrounding have been elaborated (according to the suggested procedure in ISO 14001 methodology: risk definition and prevention action proposal). As a consequence, the results of the inspection during the demo tests taking place in different orchards/plantations regarding the performance of the machineries operation, farmers’ habits and pruning residues harvesting procedures have been presented, in order to diagnose and determine possible risks that may occur and influence negatively the local environment. Similar activities have been carried out during the storage tests and transportation processes.