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Iulia-Daniela Vladu, Daniela Cana, Cristina Vaduva, Corina Grauntanu, Sorin Zaharie, Raluca Dina, Ciprian Dina, Roxana Mustafa and Eugen Mota

Chronic Kidney Disease-Mineral Bone Disorder in Diabetes Mellitus Patients

Diabetes mellitus (DM) and chronic kidney disease (CKD) are two diseases with increasing prevalence and adverse outcomes that represent an international health problem. Chronic kidney disease- mineral and bone disorder (CKD-MBD) is defined as a systemic disorder of mineral and bone metabolism due to CKD manifested by either one or a combination of the following: abnormalities of calcium, phosphorus, PTH, or vitamin D metabolism; abnormalities in bone turnover, mineralization, volume, linear growth, or strength and vascular or other soft-tissue calcification. Disturbances in mineral and bone metabolism are prevalent in CKD and are an important cause of decreased quality of life, cardiovascular morbidity and mortality; these disturbances settle in earlier and have a more severe evolution in DM patients.