The drought events frequent manifestation over the Republic of Moldova territory, in the context of climate change requires a scientific monitoring adjusted to international researchers. In recent years, internationally, the estimation of this phenomenon occurs through standardized indexes. The most used of these, being the Standardized Precipitation Index (SPI) and the Standardized Precipitation Evapotranspiration Index (SPEI). Since there is no a unified definition of drought, the World Meteorological Organization proposes to calculate the indexes, through developed calculation software. Thus, based on multi-annual data (1980-2014) a regional spatio-temporal estimation concerning drought in the Republic of Moldova was performed, thereby realizing the regional investigations framing in the international ones.