In order to solve the problem that current avoidance method of shipwreck has the problem of low success rate of avoidance, this paper proposes a method of intelligent avoidance of shipwreck based on big data analysis. Firstly,our method used big data analysis to calculate the safe distance of approach of ship under the head-on situation, the crossing situation and the overtaking situation.On this basis, by calculating the risk-degree of collision of ships,our research determined the degree of immediate danger of ships.Finally, we calculated the three kinds of evaluation function of ship navigation, and used genetic algorithm to realize the intelligent avoidance of shipwreck.Experimental result shows that compared the proposed method with the traditional method in two in a recent meeting when the distance to closest point of approach between two ships is 0.13nmile, they can effectively evade.The success rate of avoidance is high.
Older patients with acute myeloid leukemia (AML) are encumbered with poor long-term outcomes due to patient and disease characteristics. Hypomethylating agents (HMAs), acting as DNA methyltransferase (DNMT) inhibitors, have been established as a new treatment option, but they have been associated with relatively low response rates (15%–20% complete remission) when administered separately for treating elderly with AML. However, appropriate combination therapies with decitabine or azacitidine have flourished. The results of randomized trials of various combinations of HMAs with chemotherapy, histone deacetylase inhibitors, monoclonal antibodies, immunomodulatory agents, kinase inhibitors, or bexarotene are summarized.
Feng Qian, Dongbin Cheng, Wenfeng Ding, Jiesheng Huang and Jingjun Liu
Hydrological processes play important roles in soil erosion processes of the hillslopes. This study was conducted to investigate the hydrological processes and the associated erosional responses on the purple soil slope. Based on a comprehensive survey of the Wangjiaqiao watershed in the Three Gorges Reservoir, four typical slope gradients (5°, 10°, 15°and 20°) were applied to five rainfall intensities (0.6, 1.1, 1.61, 2.12 and 2.54 mm·min-1). The results showed that both surface and subsurface runoff varied greatly depending on the rainfall intensity and slope gradient. Surface runoff volume was 48.1 to 280.1 times of that for subsurface runoff. The critical slope gradient was about 10°. The sediment yield rate increased with increases in both rainfall intensity and slope gradient, while the effect of rainfall intensity on the sediment yield rate was greater than slope gradient. There was a good linear relationship between sediment yield rate and Reynolds numbers, flow velocity and stream power, while Froude numbers, Darcy-Weisbach and Manning friction coefficients were not good hydraulic indicators of the sediment yield rate of purple soil erosion. Among the three good indicators (Re, v and w), stream power was the best predictor of sediment yield rate (R2 = 0.884). Finally, based on the power regression relationship between sediment yield rate, runoff rate, slope gradient and rainfall intensity, an erosion model was proposed to predict the purple soil erosion (R2 = 0.897). The results can help us to understand the relationship between flow hydraulics and sediment generation of slope erosion and offer useful data for the building of erosion model in purple soil.
The compressive strength and water absorption of cement mortars with different water-binder ratio (0.35, 0.45 and 0.55) and fly ash content (0, 10%, 20% and 30%) under water immersion were investigated, and the correlation between them was further analyzed. The internal microstructure and phase composition of mortar was studied by scanning electron microscopy (SEM) and X-ray diffraction (XRD), respectively. The results show that the inside of mortar mixed with fly ash displayed the loose and porous microstructure. Therefore, the incorporation of fly ash reduced the compressive strength of mortar, especially the early strength, and the strength decreased with the increase of fly ash content, and the water absorption of mortar also increased. There was a linear correlation between the compressive strength and water absorption of mortar with the equation: fc = −3.838β + 62.332, where fc and β represented the compressive strength and water absorption, respectively. Therefore, when the water absorption of mortar immersed in water was measured, its corresponding compressive strength could be preliminarily inferred through this equation, which was of great significance for detecting and identifying the stability and safety of hydraulic structures.
Jiabei Li, Yanqi Zhang, Juan Wang, Dehui Qian, Hui Guo, Mingbao Song, Xiaojing Wu, Jun Jin, Junfu Huang and Lan Huang
Whether patients with coronary heart disease (CHD) and resistance to aspirin found by in vitro tests are at a greater risk of major adverse cardiovascular events (MACEs) is controversial.
To identify any association between resistance to aspirin found by in vitro tests and MACEs in patients with unstable angina pectoris (UAP).
Previously we demonstrated that 38 of 104 patients admitted to hospital with UAP showed resistance to aspirin using whole blood aggregometry (WBA). In the present study, the same cohort was observed during a 6-month follow-up. The primary end points were MACEs, including cardiovascular death, nonfatal myocardial infarction, revascularization, stroke/transient ischemic attack, or worsening UAP that required the patient to be readmitted to hospital.
During the course of 6 months, only 1 patient in the aspirin-sensitive group was lost in follow-up, and MACEs occurred in 24 patients. Patients with resistance to aspirin found by WBA did not apparently have a higher risk of MACEs compared with patients who were aspirin-sensitive (29% vs 20%, P > 0.05). Cox regression analysis showed that resistance to aspirin found by WBA appeared to have no significant correlation with 6-month clinical outcome (HR 1.56, 95% CI 0.70-3.48, P > 0.05).
Aspirin resistance, as defined by WBA, was not associated with an increased risk of MACEs in patients with UAP in a 6-month follow-up. Clarification of the clinical significance of aspirin responsiveness detected by platelet function tests requires further investigation in larger longitudinal studies.
Gang Peng, Rubo Cao, Jun Xue, Pindong Li, Zhenwei Zou, Jing Huang and Qian Ding
Background. Nasopharyngeal carcinoma (NPC) is a major cancer in southern China. Src homology phosphatase-1 (SHP-1) is a tyrosine phosphatase that regulates growth, differentiation, cell cycle progression, and oncogenesis. We determined the clinical significance of SHP-1 expression in the tumours of NPC patients from southern China who were treated with radiotherapy.
Patients and methods. SHP-1 expression was determined by real-time polymerase chain reaction (PCR) and western blotting of NPC tissue samples of 50 patients and nasopharyngeal tissues of 50 non-NPC patients who had chronic nasopharyngeal inflammation. SHP-1 expression was measured in NPC tissue samples of 206 patients by immunohistochemistry and survival analysis was performed.
Results. The tumours of NPC patients had significantly increased expression of SHP-1 at mRNA and protein levels relative to patients with chronic nasopharyngeal inflammation. Survival analysis of NPC patients indicated that SHP-1 expression was significantly associated with poor local recurrence-free survival (p = 0.008), but not with nodal recurrence- free survival, distant metastasis-free survival, or overall survival.
Conclusions. SHP-1 appears to be associated with radiation resistance of NPC cells and can be considered as a candidate marker for prognosis and/or therapeutic target in patients with this type of cancer.
Yong Yang, Shuying Huang, Junfeng Gao and Zhongsheng Qian
In this paper, by considering the main objective of multi-focus image fusion and the physical meaning of wavelet coefficients, a discrete wavelet transform (DWT) based fusion technique with a novel coefficients selection algorithm is presented. After the source images are decomposed by DWT, two different window-based fusion rules are separately employed to combine the low frequency and high frequency coefficients. In the method, the coefficients in the low frequency domain with maximum sharpness focus measure are selected as coefficients of the fused image, and a maximum neighboring energy based fusion scheme is proposed to select high frequency sub-bands coefficients. In order to guarantee the homogeneity of the resultant fused image, a consistency verification procedure is applied to the combined coefficients. The performance assessment of the proposed method was conducted in both synthetic and real multi-focus images. Experimental results demonstrate that the proposed method can achieve better visual quality and objective evaluation indexes than several existing fusion methods, thus being an effective multi-focus image fusion method.
Jian-ming Zheng, Ming-quan Chen, Meng-qi Zhu, Ning Li, Qian Li, Xin-yu Wang, Chong Huang and Guang-feng Shi
Objective To assess on-treatment serum HBsAg and HBV DNA kinetics in HBeAg-positive CHB patients to predict the efficacy of pegylated interferon (PEG-IFN) in early phase of treatment.
Methods Forty-one treatment-naive HBeAg-positive patients treated with PEG-IFNα 2a at a dose of 180 μg/week for at least 24 weeks were evaluated. Their treatment response was assessed, including normalization of serum ALT, decline of serum HBV DNA and loss of HBeAg.
Results We found that a decrease of HBV DNA level at the 4th week was positively correlated with the decrease of HBV DNA level at the 12th week and 24th week (r = 0.8202, P < 0.0001 and r = 0.6838, P < 0.0001, respectively). We observed that a decrease of HBsAg level at the 4th week was positively correlated with decrease of HBsAg level at the 12th week and 24th week (r = 0.4868, P = 0.0023 and r = 0.4251, P = 0.0109, respectively). A decrease of HBsAg level at the 24th week was positively correlated with the decrease of HBV DNA level at the 24th week (r = 0.5262, P = 0.0024). Serum level of IFN and IFN neutralizing antibody had no relationship with HBV DNA or HBsAg titers kinetics.
Conclusions The decline of serum HBV DNA and hepatitis B surface antigen at the 4th week can be used to predict the response to PEG-IFNα 2a in patients with HBeAg positive chronic hepatitis B.
The chemokine C-C motif ligand 11, also known as eotaxin-1, has been identified as a novel mediator of inflammatory bone resorption. However, little is known regarding a potential role for CCL11/Eotaxin-1 in postmenopausal osteoporosis.
The scope of this study was to explore the relationship between serum CCL11/Eotaxin-1 concentrations and disease progression of postmenopausal females with osteoporosis.
A total of 83 postmenopausal women diagnosed with osteoporosis were enrolled. Meanwhile, 82 postmenopausal women with normal bone mineral density (BMD) and 85 healthy controls inner child-bearing age were enrolled as control. The Dual-energy X-ray absorptiometry was used to examine the BMDs at the femoral neck, lumbar spine 1-4 and total hip of all participants. Serum CCL11/Eotaxin-1 levels were examined by enzyme-linked immunosorbent assay. We also included inflammation marker interleukin-6 (IL-6) as well as a serum marker of bone resorption C-telopeptide cross-linked collagen type 1 (CTX-1). The Visual Analogue Scale (VAS) and Oswestry Disability Index (ODI) were recorded to evaluate the clinical severity in POMP females.
Serum CCL11/Eotaxin-1 levels were significantly elevated in postmenopausal osteoporotic patients PMOP patients compared with PMNOP and healthy controls. We observed a significant negative correlation of serum CCL11/Eotaxin-1 levels with lumbar spine, femoral neck and total hip BMD. Furthermore, serum CCL11/ Eotaxin-1 concentrations were also positively related to the VAS and ODI scores. Last, serum CCL11/ Eotaxin-1 concentrations were positively associated with IL-6 and CTX-1 levels. These correlations remain significant after adjusting for age and BMI. Multivariate linear regression analysis demonstrated that CCL11/Eotaxin-1 could serve as an independent marker.
Serum CCL 11/Eotaxin-1 may serve as a candidate biomarker for postmenopausal osteoporosis. Therapeutics targeting CCL11/Eotaxin-1 and its related signalling way to prevent and slow progression of PMOP deserve further study.