Social media is playing an increasingly important role in reporting major events happening in the world. However, detecting events from social media is challenging due to the huge magnitude of the data and the complex semantics of the language being processed. This paper proposes MASEED (MapReduce and Semantics Enabled Event Detection), a novel event detection framework that effectively addresses the following problems: 1) traditional data mining paradigms cannot work for big data; 2) data preprocessing requires significant human efforts; 3) domain knowledge must be gained before the detection; 4) semantic interpretation of events is overlooked; 5) detection scenarios are limited to specific domains. In this work, we overcome these challenges by embedding semantic analysis into temporal analysis for capturing the salient aspects of social media data, and parallelizing the detection of potential events using the MapReduce methodology. We evaluate the performance of our method using real Twitter data. The results will demonstrate the proposed system outperforms most of the state-of-the-art methods in terms of accuracy and efficiency.
Objective: to observe the effects of moxibustion on histomorphological changes of gastric mucosa, as well as on serum IL-6、IL-8、TNF-α，Hp IgG、CD3+、CD4+、CD8+ in helicobacter pylori (Hp) infected rats, so that to better understand how the moxibustion repairs the Hp- induced gastric mucosal injury.
Methods: 40 SD rats were randomly assigned to four groups: group A (blank control), group B (Hp infection model), group C (moxibustion plus model), group D (electro-acupuncture plus model), 10 for each group. The “NaHCO3 plus Indometacin and Hp intragastric administration” method was employed to make gastritis model. Acupoints selected for “repair” purpose were Zu San Li (ST36), Zhong Wan (CV12), Guan Yuan (RN4), Pi Shu (BL20), Wei Shu(BL21). The histomorphological changes of gastric mucosa in rats were observed under light microscope after HE stain; IL-6, IL-8, TNF-α, Hp IgG values were evaluated by ELISA method; values of CD3+、CD4+、CD8+、CD4+/CD8+ were measured by flow cytometry method.
Results: compared with group A, the values of IL-6, IL-8, TNF-α, Hp IgG and CD8+ in group B were increased（P＜0.01）, whereas the values of CD3+、CD4+、CD4+/CD8+ were decreased（P＜0.01）. Compared with group B, the values of IL-8（P＜0.05）,TNF-α（P＜0.05）, IL-6（P＜0.01）, Hp IgG（P＜0.01） and CD8+ （P＜0.05） in group C were decreased, whereas the values of CD3+（P＜0.05）,CD4+（P＜0.05）,CD4+/CD8+ （P＜0.05） were increased, meanwhile such values in group D had no significant changes. Compared with group D, the values of IL-6（P＜0.05）,IL-8 （P＜0.05）and Hp IgG （P＜0.01）in group C were decreased, whereas CD4+/CD8+（P＜0.05）were increased, all those changes had statistical significance.
Conclusion: the preventive and therapeutic effects of moxibustion on Hp related gastritis might be realized by two ways- to inhibit the secretion of proinflammatory cytokines such as IL-6, IL-8 and TNF-α, or to regulate the production of immune factors (such as up-regulation of CD3+, CD4+ and down-regulation of CD8+).
Shell model calculations have been carried out for 90Nb nucleus with the model space in which the valence protons occupy the f5/2, p3/2, p1/2, and g9/2 orbitals and the valence neutrons occupy the p1/2, g9/2, d5/2, and g7/2 orbitals. According to the calculated results, the negative parity is from the contribution of the proton of the f5/2, p3/2, and p1/2 orbits. The moderate spin states of 90Nb are mainly due to the excitation of protons from the f5/2 and p3/2 orbits to the p1/2 and g9/2 orbits across the Z = 38 subshell closure, and the high spin states arise from the excitation of a single neutron from the g9/2 orbit into the d5/2 orbit across the N = 50 shell closure.
Objective: To observe the effects of electro-acupuncture (EA) on ultrastructure of gastric antrum smooth muscle cells (GASMCs) in diabetic gastroparesis (DGP) model rats, and to explore the possible mechanism underlying the therapeutic effects of EA.
Methods: Sixty Sprague Dawley rats were randomly divided into 5 groups: blank control (group A), DGP model (group B), EA point (group C), EA non-point (group D), Metoclopramide control (group E). DGP rat model was established by 2% STZ intraperitoneal injection at once, and then being fed with high-sugar-high-fat (HSHF) for 8wks. Phenol red lavage method was employed to measure gastric emptying rate (GER) and intestinal migration rate (IMR). The ultrastructure of GASMCs was observed under the electronic microscope.
Results: Compared with the blank control group, the GER and IMR in model group were decreased significantly (P＜0.05 or P＜0.01). Compared with the model group, the GER and IMR in EA point group were increased significantly(P＜0.05 or P＜0.01). Electro-acupuncture on “Zu San Li”(ST36) point, etc. has been observed improving the ultrastructure of GASMCs, as well as increasing the number of interstitial cells of Cajal (ICCs).
Conclusion: Electro-acupuncture can improve the GI motility promisingly, based on a potential underlying mechanism that the electro-acupuncture can improve the ultrastructure of gastric smooth muscle, and increase the number of ICCs.
Creeping breakdown caused by metal particles on the silicone rubber/XLPE interface of prefabricated cable joints often happens. Study on the development process of such insulation defect-led partial discharge (PD) can serve as a basis for the assessment of its severity level. In this paper, metal particles are sandwiched on the rubber/XLPE interface of a 35 kV prefabricated cable joint to simulate a creeping defect.
Calcium-sensing receptor (CaSR) is known to regulate hypoxia-induced pulmonary hypertension (HPH) and vascular remodeling via the phenotypic modulation of pulmonary arterial smooth muscle cells (PASMCs) in small pulmonary arteries. Moreover, autophagy is an essential modulator of VSMC phenotype. But it is not clear whether CaSR can regulate autophagy involving the phenotypic modulation under hypoxia.
The viability of human PASMCs was detected by cell cycle and BrdU. The expressions of proliferation protein, phenotypic marker protein, and autophagy protein in human PASMCs were determined by western blot.
Our results showed that hypoxia-induced autophagy was considerable at 24 h. The addition of NPS2390 decreased the expression of autophagy protein and synthetic phenotype marker protein osteopontin and increased the expression of contractile phenotype marker protein SMA-ɑ and calponin via suppressing downstream PI3K/Akt/mTOR signal pathways.
Our study demonstrates that treatment of NPS2390 was conducive to inhibit the proliferation and reverse phenotypic modulation of PASMCs by regulating autophagy levels.
With regard to the inefficient application of a food processing information system due to shortage of the knowledge acquisition measure and self-updating function of knowledge, a method of constructing an online aided decision making knowledge base for quality and security of food processing, based on regular expression, is discussed in the paper. Firstly, the method establishes an online aided decision making knowledge base for quality and security of food processing based on regular expression; and then an automatic knowledge inference engine is applied to update the knowledge in the base, combined with industry experts’ experience knowledge. Continuous deriving of food processing knowledge can be realized based on the inference engine. The research will greatly enhance the efficiency and applicability of obtaining knowledge from an online aided decision making system for quality and security of food processing.