Triptans are specific drugs for migraine attack, their use leads to selective vasoconstriction, while the inflammatory condition that usually occurs during migraine is reduced. The structurally indolamine derivatives are selective agonists of the serotonin 1B/1D receptor. This review presents the history, representatives, production, and physico-chemical properties of triptans, but also discusses their pharmacological properties and mechanism of action.
Objective: Miconazole, an imidazole antifungal derivative, is a very hydrophobic compound, a major drawback in obtaining topical pharmaceutical formulations with optimal bioavailability. Cyclodextrins (CDs) may increase local drug delivery by enhancing the drug release and/or permeation. The aim of the study is the characterization of inclusion complexes between miconazole and different CD derivatives.
Methods: Several CD derivatives were tested in the experiments. The binary systems between miconazole and different CDs were prepared in 1:1 molar ratios by physical-mixture and kneading methods. Differential scanning calorimetry (DSC) and Fourier transformed-infrared spectroscopy (FT-IR) methods were used to characterize solid state interactions between miconazole and CDs in their binary systems.
Results: The FT-IR analysis suggests the formation of a new solid phase, indicating a molecular interaction between the components. The DSC analysis sustains the hypothesis of formation of partial inclusion complexes between miconazole nitrate and CD.
Conclusion: The thermic behaviour of the complexes depends both on the preparation method and the composition of the products.