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  • Author: Oana Stoica x
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Introduction: Pediatric Dentistry offers a completely different approach compared to that of adults especially in terms of patient cooperation, problems with growth and development and problems related to dental restoration in the context of a developing dentition.

Aim of the study: The purpose of this study was to assess the prevalence of primary and secondary dental dystrophies among preschool and school-age children.

Material and Methods: The group of 113 subjects with ages between 3 and 11 years was selected from two primary and preschool education establishments from Târgu-Mures. Simultaneously with the clinical examination of dental surfaces, 150 questionnaires were distributed to the parents of the subjects. The dystrophies determined clinically were arranged in a certain category of number, form, volume and structure and were correlated with the answers to the questionnaires.

Results: According to the data most cases of dental dystrophies are represented by dental fluorosis followed by severe early childhood caries S-ECC, and in equal percentages are present dyschromia, imperfect amelogenesis, MIH hypomineralization, dental fusion, macrodontia and hyperdontia.

Conclusions: There are significant correlations between the primary dental dystrophies and factors that intervened during pregnancy and in the post-natal period, both critical periods for dental formation and development.


It has already been demonstrated that a complete brain renin-angiotensin system (RAS) exists distinctly separate from the peripheral system and is implicated in complex functions such as memory, emotional responses and pain. Regarding the implications of angiotensin II (the main bioactive peptide of RAS) in pain, although there are many studies in this area of research, most of the results are controversial. Also, it seems that oxidative stress follows angiotensin II infusion, but the role of AT1 vs. AT2 receptors is not well established. In this context, we were interested in studying the effects of central RAS on nociception, through the intracerebroventricular administration of losartan and PD-123177 (antagonists for the AT1/AT2 receptors), as well as an ACE inhibitor (captopril) and also angiotensin II in rats, which were subsequently tested using the hot-plate task, a well known behavioral test for pain perception. We present here the analgesic effect of angiotensin II administration, as shown by in creased latency-time in the hot-plate, as well as a nociceptive effect of angiotensin II blockers like AT1 and AT2 specific antagonists (losartan and PD-123177) and an ACE inhibitor (captopril), as their administration resulted in decreased latency-time. Moreover, we demonstrated a significant correlation between the results of the nociceptive behavioral task and the levels of some main oxidative stress markers. This provides additional evidence for an analgesic effect of Ang II administration, as well as for a nociceptive effect of Ang II blockers. Moreover, a significant correlation between the nociception and angiotensin II-induced oxidative stress is presented.


Introduction. Celiac disease is a chronic bowel disease with a prevalence of 1% in the general population. This condition, immune-mediated, may exhibit multiple extra-intestinal changes, including the liver.

Case presentation. We present the case of a 43-year-old patient presenting in our clinic for fatigue, associated with cytolytic and cholestatic hepatic syndrome with an onset of 10 years. During this time, the patient performed multiple investigations with the exclusion of viral, autoimmune etiology, primitive biliary cirrhosis and Wilson's disease. An abdominal ultrasound recorded an elongated, with an infundibular septum gallbladder. Abdominal computer tomography did not detect any changes. The final diagnosis is chronic alithiasic cholecystitis receiving hepatoprotective treatment with symptom relief and improved hepatic disorders. Over the past 2 years, the patient was diagnosed with osteoporosis (T score = -2.7 followed by treatment with Calcium and Vitamin D and improvement in T score to -2.1), and an iron deficiency anemia corrected with oral iron treatment. Upon resuming the anamnesis, we notice the presence of an intermittent bloating associated with diarrhea. Positive anti-transglutaminase antibodies required upper endoscopy with biopsy witch confirmed celiac disease.

Conclusion. Despite the rather low prevalence of celiac disease in the etiology of hepatocytolysis, it is important to investigate its presence in the context of hepatic changes with uncertain etiology. This case motivates us to be rigorous in looking for secondary causes of hepatic impairment even in patients with apparently benign changes.


Objectives. This study aimed to examine peripheral artery disease severity impact on psychological profile of arteriopathy patients.

Material and methods. The prospective study included consecutive PAD patients admitted to the 2nd Department of Internal Medicine and the Department of Cardiology of the Emergency Clinical Hospital “Sf. Spiridon” Iasi, between January and September, 2017.

Rezults. The group included 139 PAD patients, 80.6% male and 19.4% female, with an average age of 63.23±9.44 years. PAD stages have a very strong association with level of quality of life (p<0.0001). All Leriche-Fontaine classification categories were significantly associated with the depressive symptoms (p<0.0001). The stress level was moderate in stages IIA, IIB and III and extremely severe in the terminal stage. The prevalence of anxiety was lowest in incipient PADstages with the highest value in stage III.

Conclusions. The fragment of the PhD study presented the psychological profile in the PAD staging and advocates a personalized, wide-ranging approach to the arteriopathy patient including pain and depressive-anxiety management, with amajor impact on the quality of life at terminal stages.


α, β, θ defensins represent a family of small antimicrobial peptides expressed predominantly by a series of cells, including neutrophils, monocytes-macrophages and epithelial cells that are involved in defense mechanisms against viral infections. β-defensins are the most widespread in this family being encountered in oral, digestive, urogenital mucosa and cutaneous lesions. β-defensins directly inactivate certain viruses, including the human papillomavirus(HPV) suppressing viral replication by altering target cells. Considering these aspects, we investigated the immunohistochemical expression of β-defensin-1 and 2 in HPV-induced epithelial lesions. For this study, tumoral and normal mucosal tissue fragments were collected from 10 patients aged between 31-60years, with previously confirmed HPV infection, diagnosed clinically and histopathologically with cervical carcinoma. Patients did not receive any chemotherapy or radiotherapy before the biopsy procedure. The tissue fragments were processed by the standard immunohistochemistry technique using anti-β-defensin-1 and 2 antibodies(Bioss Antibodies). The samples examination revealed weak positive(+) membrane, cytoplasmic and nuclear IR for hβD-1 in basal layer of normal cervical mucosa and moderate positive(++) membrane and cytoplasmic IR in squamous epithelium. For dysplastic HPV-associated tissues we highlighted a nuclear moderate positive(++) IR.For hβD-2, IR in basal layer of the normal mucosa was lower(+) compared with dysplastic cells IR and showed a strong expression(+++) at membrane, cytoplasmic and nuclear level in koilocytes of patients with HPV-associated dysplasia. It was also observed a moderate positive (++) IR in basal layer of dysplastic cells of patients without HPV. The obtained results are in agreement with some literature data, which highlighted the fact that hβD-1 and hβD-2 are very important components of the molecular pattern in HPV-induced lesions.