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Mostafa Hussein, Abdel-Hamid Kafafy, Samia Abdel-Moty and Ola Abou-Ghadir

Synthesis and biological activities of new substituted thiazoline-quinoline derivatives

5-Acyl-8-hydroxyquinoline-2-(3'-substituted-4'-aryl-2,3-dihydrothiazol-2'-ylidene)hydrazones, 5a-e to 10a-c, were prepared by the reaction of appropriate 5-acyl-8-hydroxyquinoline-4-substituted thiosemicarbazones 3a-e and phenacyl bromides 4a-e. Structures of the new compounds were verified on the basis of spectral and elemental analyses. Twenty-eight new compounds were tested for their possible antimicrobial activities. Most of the tested compounds showed weak to moderate antibacterial activity against most of the bacterial strains used in comparison with gatifloxacin as a reference drug. The test compounds showed weak to moderate antifungal activity against tested fungi in comparison with ketoconazole as a reference drug. On the other hand, the newly synthesized compounds were tested for their anti-inflammatory effects and most of them showed good to excellent anti-inflammatory activity compared to indomethacin. Moreover, ulcerogenicity and the median lethal dose (LD 50) of the most active anti-inflammatory compounds 6b and 9e were determined in mice; they were non-toxic at doses up to 400 mg kg-1 after i.p. administration.

Open access

Jihan Hussein, Ehab Mostafa, Maha El-Waseef, Zakarya El-Khayat, Ehsan Badawy and Dalia Medhat

Effect of Omega-3 Fatty Acids on Erythrocyte Membrane in Diabetic Rats

Background: Diabetes mellitus is a metabolic disease characterized by chronic hyperglycemia resulting from defects in insulin secretion, almost always with a major contribution from insulin resistance which may be affected by cell membrane fatty acids and phospholipids fractions.

Aim: To evaluate the effects of omega-3 fatty acids on erythrocyte membrane and also in decreasing oxidative stress in diabetic rats.

Materials and Methods: Sixty healthy male albino rats weighting 180-200 g divided into five groups included: control, Omega-3, diabetic, prophylactic and treated groups. Fasting blood samples were collected from all groups for determination of fasting blood sugar, plasma insulin, erythrocyte membrane lipid profile, phospholipids fractions by HPLC, plasma and erythrocyte membrane lipid peroxidation product (malondialdehyde) and reduced glutathione.

Results: Fasting blood sugar and plasma insulin sensitivity were improved by Omega-3 administration, also reduced glutathione improved by Omega-3 in both erythrocyte membrane and plasma, while, malondialdehyde decreased indicated the decrease of oxidative stress by Omega-3 administration.

Conclusion: Omega-3 supplementation increased insulin sensitivity by improving cell membrane contents especially phospholipids fractions.