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  • Author: Monika Podhorecka x
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Neutropenia in adults – significant diagnostic issue

Abstract

Introduction. Neutropenia, a disorder quite commonly encountered in blood tests, is defined as a decrease in the absolute neutrophil count below 1500/µl. Neutropenia may not be clinically significant, whereas it sometimes indicates serious haematological, infectious or rheumatic diseases. The reduction of the number of neutrocytes below 500/µl is referred to as ’agranulocytosis’. Such decrease in neutrophil count impairs host defense and makes the patient more vulnerable to bacterial and fungal infections, which may lead to life-threatening sepsis.

Aim. This review presents the causes of congenital and acquired neutropenia, with particular attention to drug-induced neutropenia, which may occur due to the intake of the broad spectrum of drugs, including over-the-counter drugs. The article also attempts to answer the question of how the neutropenia and agranulocytosis should be diagnosed and treated.

Methods. The publication is based on the analysis of the literature (PubMed database).

Results. It has to be emphasized that a thorough physical examination and appropriate additional tests make it possible to diagnose a disease that causes neutropenia. This allows for the implementation of appropriate therapeutic procedures, and consequently, leads to avoidance of serious infections.

Open access
Polish hematology on the Internet

Abstract

The end of 20th and the beginning of 21st century have brought an intense development of the IT applications, without which people cannot imagine life. In the last years, the Internet has been playing more and more crucial role. It has become a valuable source of information for a big group of people, both patients and medical staff. Pharmaceutical syndicates, scientific units, magazines, medical clinics and departments, as well as individuals design their own websites. This article introduces a review of the most important websites about hematology.

Open access
Advances in hematology – research that revolutionized patient care

Abstract

In the last decades, substantial strides have been made in the diagnosis, treatment, and prevention of blood diseases. The new drugs to be used in combination with cytostatic therapy have been developed, based on increased understanding of the biology of neoplasia. The diagnosis of several diseases is based exclusively on cytogenetic and molecular analysis which has become a part of routine diagnostic management. Moreover, molecular definition has allowed the introduction of therapy targeted at molecular change characteristic for a given disease. The introduction of novel agents for the treatment of hematological disorders has resulted in a great improvement in response rate and median survival.

The aim of this study is to show advances and possible future directions in the treatment of chosen hematological malignancies during the recent decades.

Open access
Zespół hemofagocytowy indukowany terapią hormonalną – studium przypadku klinicznego

Streszczenie

Zespół hemofagocytowy (ang. hemophagocytic lymphohistiocytosis – HLH) charakteryzuje się nieprawidłową aktywacją układu immunologicznego, u podłoża której leżą zmiany genetyczne lub nabyte zaburzenia cytotoksyczności limfocytów T i NK. Objawy kliniczne są niespecyficzne i różnorodne, a postawienie rozpoznania, pomimo dostępności badań dodatkowych, jest niezwykle trudne. W artykule zaprezentowano przypadek kliniczny chorej, u której pierwotnie w obrazie klinicznym dominowała nawracająca gorączka oraz zmiany skórne sugerujące rozpoznanie rumienia guzowatego. Pomimo rozpoczęcia steroidoterapii oraz stosowania empirycznej antybiotykoterapii stan pacjentki nie ulegał poprawie. Do objawów klinicznych dołączyły się splenomegalia oraz zaburzenia w badaniach dodatkowych: trójukładowa cytopenia, hiperferrytynemia, hipertriglicerydemia, hipofibrynogenemia. Ponadto w obrazie histopatologicznym szpiku kostnego stwierdzono obecność hemofagocytów. Na podstawie obrazu klinicznego oraz badań dodatkowych postawiono rozpoznanie HLH. W terapii zastosowano chemioterapię zgodnie z protokołem HLH-2004, uzyskując całkowitą remisję.

Open access