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Open access

Ashraf Alias, Muna Al-Zubaidy, Yaareb Mousa and Fouad Mohammad

Plasma and whole brain cholinesterase activities in three wild bird species in Mosul, IRAQ: In vitro inhibition by insecticides

Plasma and brain cholinesterase activities were determined in three wild bird species to assess their exposure to organophosphate and carbamate insecticides which are used in agriculture and public health. In the present study, we used an electrometric method for measurement of cholinesterase activities in the plasma and whole brain of three indigenous wild birds commonly found in northern Iraq. The birds used were apparently healthy adults of both sexes (8 birds/species, comprising 3-5 from each sex) of quail (Coturnix coturnix), collard dove (Streptopelia decaocto) and rock dove (Columba livia gaddi), which were captured in Mosul, Iraq. The mean respective cholinesterase activities (Δ pH/30 minutes) in the plasma and whole brain of the birds were as follows: quail (0.96 and 0.29), collard dove (0.97and 0.82) and rock dove (1.44 and 1.42). We examined the potential susceptibility of the plasma or whole brain cholinesterases to inhibition by selected insecticides. The technique of in vitro cholinesterase inhibition for 10 minutes by the organophosphate insecticides dichlorvos, malathion and monocrotophos (0.5 and 1.0 μM) and the carbamate insecticide carbaryl (5 and10 μM) in the enzyme reaction mixtures showed significant inhibition of plasma and whole brain cholinesterase activities to various extents. The data further support and add to the reported cholinesterase activities determined electrometrically in wild birds in northern Iraq. The plasma and whole brain cholinesterases of the birds are highly susceptible to inhibition by organophosphate and carbamate insecticides as determined by the described electrometric method, and the results further suggest the usefulness of the method in biomonitoring wild bird cholinesterases.

Open access

Mohammad Ali Alizadeh and Ali Ashraf Jafari

Abstract

Anthemis L. is a genus of aromatic flowering plants in the family Asteraceae and is native to Iran. In this research, 62 accessions of four chamomile species including Anthemis tinctoria, A. triumfetti, A. haussknechtii and A. pseudocotula were evaluated for morphological traits. Four experiments were conducted using a randomized complete block design with three replications at the Research Institute of Forest and Rangeland, Tehran, Iran in 2011. Data were collected for the morphological traits for all of the species and essential oil content for A. triumfetti and A. pseudocotula. The results showed that plant height was positively correlated with canopy area for all of the species except A. triumfetti (p < 0.01). There were positive correlations between flower number with plant height and canopy area in both A. tinctoria and A. haussknechtii (p < 0.01). Fresh and dry weight were positively correlated with canopy area and plant height in all of the species (p < 0.01), except A. tinctoria for canopy area and A. triumfetti for plant height. GDD had a positive correlation with canopy area for A. triumfetti (p < 0.05). There was a positive correlation between essential oil yield and plant height, fresh and dry weight in A. triumfetti and A. pseudocotula (p < 0.05). Using cluster analysis (Ward method), the accessions of A. triumfetti, A. tinctoria, A. haussknechtii and A. pseudocotula were grouped into 3, 2, 4 and 2 clusters, respectively. The results of cluster analysis separated the accession based on shoot yield, morphological traits and maturity. In some items, the accessions within each cluster were coordinated with their geographical provenance.

Open access

Soheil Pardis, Raziyeh Zare, Zohreh Jaafari-Ashkavandi, Mohammad Javad Ashraf and Bijan Khademi

Abstract

Objective: Twist is an important transcription factor that induces epithelial-mesenchymal transition and therefore plays an important role in tumor progression. There are a few studies on Twist expression in salivary gland carcinomas. The aim of this study was to evaluate and compare the expression of Twist in the most common benign and malignant salivary gland tumors and to determine whether its expression was correlated with any tumor characteristics.

Material and Method: In this retrospective cross-sectional study, 45 cases including 11 cases of normal salivary gland, 12 pleomorphic adenomas, 12 adenoid cystic carcinomas and 10 mucoepidermoid carcinomas were enrolled. The mean and intensity of Twist expression were evaluated immunohistochemically and were compared using statistical analysis.

Results: The expression of Twist was higher in malignant salivary gland tumors in comparison with normal glands and benign tumors (p= 0.03). It was also higher in pleomorphic adenomas in comparison with normal tissue. Adenoid cystic carcinomas and mucoepidermoid carcinomas showed no significant difference in Twist expression (p= 0.50). There was no correlation with the size, stage or grade of tumor.

Conclusion: The findings showed that Twist might play a role in the formation of salivary gland neoplasm and also may affect malignant transformation and tumoral invasion. The exact mechanism of this marker and the possibility of using it as a therapeutic target require further investigation.

Open access

Mohammad Ashraf and Bilal Ahmad Wani

Abstract

The purpose of this paper is to investigate identities with Jordan *-derivations in semiprime *-rings. Let ℛ be a 2-torsion free semiprime *-ring. In this paper it has been shown that, if admits an additive mapping D : ℛ→ℛsatisfying either D(xyx) = D(xy)x*+ xyD(x) for all x,y, or D(xyx) = D(x)y*x*+ xD(yx) for all pairs x, y, then D is a *-derivation. Moreover this result makes it possible to prove that if satis es 2D(xn) = D(xn− 1)x* + xn− 1 D(x) + D(x)(x*)n− 1 + xD(xn− 1) for all x and some xed integer n ≥ 2, then D is a Jordan *-derivation under some torsion restrictions. Finally, we apply these purely ring theoretic results to standard operator algebras 𝒜(). In particular, we prove that if be a real or complex Hilbert space, with dim() > 1, admitting a linear mapping D : 𝒜() → ℬ() (where () stands for the bounded linear operators) such that

2D(An)=D(An1)A*+An1D(A)+D(A)(A*)n1+AD(An1)

for all A𝒜(). Then D is of the form D(A) = AB−BA* for all A𝒜() and some fixed B(), which means that D is Jordan *-derivation.

Open access

Mohammad Ali Alizadeh, Ali Ashraf Jafari and Sayed Esmaiel Sayedian

Abstract

To evaluate the seven species of Tanacetum genus - Tanacetum balsamita, T. parthenium, T. pinnatum, T. polycephalum, T. tabrisianum, T. uniflorum, and T. vulgare - an experiment was conducted in Karaj Iran. Data were recorded for plant canopy cover, plant height, flower number per plant, aerial biomass yield, time required for flowering, growing degree days to flowering (GDD), essential oil percentage and yield. Results showed that T. parthenium had higher mean values for plant canopy cover, plant height and flower number per plant whereas the species of T. parthenium, T. balsamita and T. vulgare had higher aerial biomass yield in comparison to the other species. The T. balsamita coupled with aerial biomass yield had the highest essential oil concentration. The T. tabrisianum and T. uniflorum were earliest ripening species due to lowest GDD. Essential oil yield was positively and significantly correlated with the traits that are components of aerial mass, indicating that selection for breeding new cultivars should focus on increased aerial biomass yield, late flowering and high flower number.

Open access

Mohammad Ashraf, Shakir Ali and Bilal Ahmad Wani

Abstract

Let ℌ be an in finite-dimensional complex Hilbert space and A be a standard operator algebra on ℌ which is closed under the adjoint operation. It is shown that every nonlinear *-Lie higher derivation D = {δn}gn∈N of A is automatically an additive higher derivation on A. Moreover, D = {δn}gn∈N is an inner *-higher derivation.

Open access

Mohammad Ashraf, Nazia Parveen and Bilal Ahmad Wani

Abstract

Let be the triangular algebra consisting of unital algebras A and B over a commutative ring R with identity 1 and M be a unital (A; B)-bimodule. An additive subgroup L of A is said to be a Lie ideal of A if [L;A] ⊆ L. A non-central square closed Lie ideal L of A is known as an admissible Lie ideal. The main result of the present paper states that under certain restrictions on A, every generalized Jordan triple higher derivation of L into A is a generalized higher derivation of L into A.

Open access

Azadeh Andishehtadbir, Ali Dehghani Najvani, Soheil Pardis, Zohreh Jafari Ashkavandi, Mohammad Javad Ashraf, Bijan Khademi and Fereshteh Kamali

ABSTRACT

Objective: Metastasis-associated protein 1 (MTA1) has been associated with poor prognosis in several carcinomas. Recent investigation has found that in different tumors, MTA1 protein significantly correlates with tumor angiogenesis, suggesting that MTA1 may be a possible angiogenesis-promoting molecule in malignant tumors. Thus, the current study was performed to determine the role of MTA1 protein in the biological behavior of oral squamous cell carcinoma and its relation with tumor angiogenesis.

Material and Method: In this study, 44 oral squamous cell carcinomas and 15 normal epitheliums were reviewed by IHC staining for MTA1 and CD105.

Results: Frequency of MTA1 expression in SCCs was recorded as 97.7%, which was significantly higher than that of the control group (33.3%). Mean percentage of MTA1 expression in oral squamous cell carcinomas was 76.88 ± 25.33% which was significantly higher than that of the control group (22.81 ±10.83). Our data showed a correlation between MTA1 expression with lymph node metastasis, tumor size and, stage. Evaluation of the correlation between MTA1 protein expression and micro vessel density showed that high micro vessel density was detected more frequently in tumors with MTA1 protein overexpression than in those without overexpression.

Conclusion: In the present study, high expression of the MTA1 protein was seen in oral squamous cell carcinoma, and was closely associated with tumor progression and increased tumor angiogenesis. The findings may indicate that MTA1 protein has clinical potentials as a useful indicator of progressive phenotype, a promising prognostic predictor to identify patients with poor prognosis and may be a potential novel therapeutic target of anti-angiogenesis for patients with oral squamous cell carcinoma.

Open access

Reem Elmaghloub, Ashraf Elbahrawy, Gamal El Didamony, Ahmed Elwassief, Abdel-Gawad Saied Mohammad, Ahmed Alashker, Hendawy Zedan, Abdallah Mahmoud Abdallah, Mahmoud Haddad Hemidah, Amr Elmestikawy, Mohamed El Fayoumei, Hossam Shahba, Ahmed Gawish, Mohamed Hanafy Morsy, Alaa Hashim, Mohamed Ali Abdelbaseer, Yoshihide Ueda, Tsutomu Chiba and Hafez Abdelhafeez

Abstract

Background and Objectives

Health Care Workers (HCWs) are at a high risk of needle stick injuries and HBV infection in Egypt; this problem is further aggravated by low Hepatitis B (HB) vaccination coverage. Limited data are available on the prevalence of HBV infection in Egyptian HCWs. In this study, we aimed to assess the HBV infection rate and genotypes among Egyptian HCWs.

Methods

Five hundred and sixty-four (564) HCWs were included. Of them, 258 (45.74%) were health care providers and 306 (54.25%) were non-health care providers. All HCWs completed both the study questionnaires and provided a blood sample for HBV testing. Indeed, all HCWs were tested for Hepatitis B surface antigen (HBsAg) and antibody to Hepatitis B core antigen (anti-HBc), by enzyme-linked immunosorbent assay. HBVDNA was checked for HCWs who tested positive for HBsAg and/or anti-HBc, by nested Polymerase Chain Reaction (PCR). HBVDNA positive HCWs were further subjected to HBV genotyping.

Results

The mean age of included HCWs was 33.0 ± 9.8 years, of whom 319 (56.56%) were males. The mean duration of health care work was 9.3 ± 6.7 years. The frequency of HBsAg and anti-HBc were 1.4%, and 24.5%, respectively. Old age and prolonged duration of health care work were significantly associated with anti-HBc seropositivity. Among 140 HCWs positive for HBsAg and/or anti-HBc, 14 (10 %) had positive HBVDNA by PCR. HBV/E (n = 7), HBV/D (n = 3) and co-infection with E and D (n = 4) genotypes were detected.

Conclusion

Egyptian HCWs have a significantly high rate of HBV exposure. The detection of HBV/E genotype among Egyptian HCWs suggests prevalent transmission of HBV/E among Egyptian populations.