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  • Author: Mohamed Abd El-Maksoud x
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Open access

Engy Bakeer, Rasha Radwan, Ahmed El Mandoury, Abdullah Abd El Rahman, Mohamed Gad and Sahar Abd El Maksoud

Summary

Background: Recent studies have highlighted the role of anti-Müllerian hormone (AMH) in numerous ovarian disorders. Polycystic Ovary Syndrome (PCOS) is one of the major causes of infertility in Egypt. Several reports have linked PCOS with vitamin D deficiency. This investigation illustrates the possibility of using serum AMH for PCOS diagnosis in infertile Egyptian females, determines the variables affecting it and correlates it with serum 25(OH)D, testosterone, dyslipidemia and anthropometric parameters.

Methods: All parameters were assessed either with ELISA or colorimetrically in 53 infertile PCOS women and 17 age matched apparently healthy controls diagnosed according to Rotterdam consensus.

Results: Serum AMH, total testosterone, triacylglycerol (TG) levels and BMI were significantly higher in PCOS group compared to healthy controls (p=0.0239, p=0.0381, p=0.0457, and p=0.0067, respectively), while serum 25(OH)D levels and HDL-cholesterol (HDL-C) were significantly lower (p=0.0397 and p=0.0443, respectively). No significant correlation existed between AMH and 25(OH) D, BMI and dyslipidemia markers. AMH was found to have a significant negative correlation with age and a highly significant positive one with total testosterone in PCOS group (r=-0.303, p=0.027 and r=0.370, p=0.008, respectively). In the receiver operating characteristic curve of AMH, the cut-off value was 42.63 pmol/L with a specificity of 59% and a sensitivity of 82%. Multivariate regression analysis showed total testosterone to be the only determinant for AMH (β=0.381 and p=0.038).

Conclusions: There should be a future trend of using AMH as a diagnostic marker for PCOS in Egyptian females. The variation in serum AMH levels is determined by total testosterone.

Open access

Mie Afify, Nervana Samy, Mohamed Abd El-Maksoud, Maha Hasheim, Omnia Saleh and M. Elnemr

Abstract

Background: Obesity is a condition that results from chronic disruption of energy balance where energy intake continuously exceeds energy expenditure and accumulation of body fat results

Objective: We evaluated the relationships between ghrelin and leptin with the metabolic state of normal weight, overweight, and obese Egyptian women.

Methods: We studied 82 subjects with ages from 43 to 65. They were free of endocrine-related disease and divided into three groups according to their body mass index (BMI), group 1 with BMI less than 25 kg/m2, group 2 with BMI between 25 to 30 kg/m2, and group 3 with BMI more than 30 kg/m2. Ghrelin and leptin were determined by ELISA technique. Insulin resistance was measured by homeostasis model assessment. Lipid profile was determined in all groups.

Results: Fasting plasma levels of ghrelin were lower in overweight and obese groups compared to normal weight control group. There was statistically significant negative correlation of ghrelin levels with leptin, BMI and HOMA. Results showed that higher concentrations of fasting leptin were found in overweight and obese groups compared with the normal weight control group. There was statistically significant positive correlation between leptin and other biochemical parameters, insulin, BMI, and HOMA.

Conclusion: Ghrelin and leptin may be associated with obesity. These markers can be of value when assessing management.