Search Results

You are looking at 1 - 7 of 7 items for

  • Author: Milena Milovanović x
Clear All Modify Search
Open access

Milena Mirković and Ljubica Milovanović

Rezime

Savremeni uslovi poslovanja zahtijevaju od preduzeća brzo mijenjanje, prilagođavanje i konstantno usavršavanje. Opstanak, rast i razvoj na sve većem i dinamičnijem tržištu mogu obezbijediti preduzeća koja na vrijeme dođu do potrebnih znanja, informacija i tehnologije. To su najčešće najpotrebniji resursi za rast i razvoj i za ostvarenje postavljenih ciljeva preduzeća. Nerijetko se dešava da preduzeća ne raspolažu svim navedenim resursima i do njih, u savremenim uslovima poslovanja, dolaze na osnovu razvoja međunarodnog transfera. Međunarodna trgovina obezbjeđuje brži i lakši transfer tehnologije i znanja između zemalja na različitim krajevima svijeta. Takav način funkcionisanja i poslovanja preduzeća, tj. transfer tehnologije i znanja donosi preduzeću brojne prednosti i olakšava mu razvojni put.

Open access

Milena Jovanovic, Zeljko Todorovic, Dragan Milovanovic, Branislava Draskovic, Andreja Todorovic and Dejan Petrovic

Abstract

Prevalence of cognitive disorders is high in maintenance hemodialysis patients. Montreal cognitive assessment (MoCA) is used for detecting and evaluation of cognitive disorder degree in this patient population. In examined patient population, only 5 (12.5%) of them had normal cognitive function (MoCA ≥26). Mild cognitive impairment (MoCA 18-26) was found in 65.9% (29) patients, while moderate cognitive disorder (MoCA 10-17) was detected in 6 (21.6%) patients. Major cognitive disorder wasn’t detected in examined population. Statistically signifi cant correlation was not established between laboratory parameters and overall MoCA score. Statistically signifi cant correlation, however, was established between MoCA item that evaluates space and time orientation and intermediate secondary hyperparathyroidism and space and time orientation and severe secondary hyperparathyroidism. Hemodynamic instability during hemodialysis and silent ischemia of the brain are increasing risk of appearance of cognitive disorders in maintenance hemodialysis patients.

Open access

Milena Jovanovic, Zeljko Todorovic, Dragan Milovanovic, Branislava Draskovic, Andreja Todorovic and Dejan Petrovic

Abstract

Prevalence of cognitive disorders is high in maintenance hemodialysis patients. Montreal cognitive assessment (MoCA) is used for detecting and evaluation of cognitive disorder degree in this patient population. In examined patient population, only 5 (12.5%) of them had normal cognitive function (MoCA ≥26). Mild cognitive impairment (MoCA 18-26) was found in 65.9% (29) patients, while moderate cognitive disorder (MoCA 10-17) was detected in 6 (21.6%) patients. Major cognitive disorder wasn’t detected in examined population. Statistically significant correlation was not established between laboratory parameters and overall MoCA score. Statistically significant correlation, however, was established between MoCA item that evaluates space and time orientation and intermediate secondary hyperparathyroidism and space and time orientation and severe secondary hyperparathyroidism. Hemodynamic instability during hemodialysis and silent ischemia of the brain are increasing risk of appearance of cognitive disorders in maintenance hemodialysis patients.

Open access

Milena Jurisevic, Gordana Radosavljevic, Aleksandar Arsenijevic, Marija Milovanovic, Nevena Gajovic, Dragana Djordjevic, Jelena Milovanovic, Bojana Stojanovic, Aleksandar Ilic, Tibor Sabo and Tatjana Kanjevac

Abstract

The design of platinum based drugs is not a new field of interest. Platinum complexes are widely used as anticancer agents and currently, approximately 30 platinum(II) and platinum(IV) entered into some of the phases of clinical trials. A special place in today’s research belongs to platinum complexes with diammine ligands. A large number of edda (ethylenediamine- N, N’-diacetate)-type ligands and their corresponding metal complexes has been successfully synthesized. This article summarizes recent progress in research on edda-type-platinum complexes. Some of these agents achieves better effect compared to the gold standard (cisplatin). It has been shown that there is a possible relationship between the length of the ligand ester group carbon chain and its cytotoxic effect. In most cases the longer the ester chain is the greater is the antitumor activity. Of particular interest are the noticeable effects of some new platinum compound with edda-type ligand on cell lines that are known to have a high level of cisplatin-resistance. Exanimate complexes appear to have a different mode of mechanism of action compared with cisplatin which includes apoptotic and necrotic cell death. There are indications that further investigations of these compounds may be very useful in overcoming the problems associated global cancer statistic.

Open access

Snežana Radoš, Milena Milovanović, Milica Rajović, Kristina Kostić, Ivana Tufegdžić and Lidija Kandolf Sekulović

Abstract

Porokeratosis belongs to a group of disorders of keratinization that are characterized by the histopathological feature of the cornoid lamella, a column of tightly fitted parakeratotic cells. The etiology of porokeratosis is still unclear. Different variants of porokeratosis (PK) have been subsequently recognized, each with its own specific properties in terms of morphology, distribution and clinical course. Linear porokeratosis is one of the variants of porokeratosis, a rare disorder of keratinization that may develop into several epidermal malignancies, squamous cell carcinoma being the most frequent among all of them. Thus, a clinical surveillance for malignancy is an imperative. We present a case of a 54-year-old man with non-healing ulcer of the lower leg caused by squamous cell carcinoma arising on long-standing linear porokeratosis. The treatment included wide excision of tumor with the reconstruction of the area. Acitretin was prescribed for linear porokeratosis treatment. The follow-up of our patient so far has shown that he does not have new malignant lesions after surgical excision.

Open access

Milena Milovanović, Željko Mijušković, Lidija Kandolf Sekulović, Olga Radić-Tasić, Olivera Tarabar, Danijela Mijušković-Janković and Milica Rajović

Abstract

In 2005, the World Health Organization - European Organization for Research and Treatment of Cancer (WHOEORTC) classified cutaneous B-cell lymphomas into 4 categories: primary cutaneous marginal zone B-cell lymphoma (PCMZL), primary cutaneous follicle center lymphoma (PCFCL), primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL-LT), and primary cutaneous diffuse large B-cell lymphoma, other (PCDLBCL-O). The absence of evident extra-cutaneous disease is a necessary condition for the diagnosis of primary cutaneous B-cell lymphomas, because they have a completely different clinical behavior and prognosis from their nodal counterparts. PCDLBCL-O basically represents a morphological variation, lacking the typical features of PCDLBCLLT, neither confirming the definition of PCFCCL, but on the clinical ground, its behavior seems at least to partially overlap the indolent course of PCFCCL. In fact, the present WHO lymphoma classification from 2008 overcame the previous WHO-EORTC classification, including at least a part of PCDLBCL-O within the spectrum of PCFCCL. However, owing to the rarity and heterogeneity of the PCDLBCL-O, the precise clinicopathological characteristics have not been well characterized and the optimal treatment for this group of lymphomas is yet to be defined. Nevertheless, dermatologists and pathologists should be aware of this entity in order to avoid unnecessary aggressive treatment. We present a case of a 46-year-old Caucasian male with one large round-shaped tumor and a few scattered nodules localized on the back. The histopathological features of the lesion corresponded to PCDLBCL-O. The patient follow-up showed that he was disease-free three months after surgical excision of the lesions and adjuvant local radiotherapy. No additional therapy was introduced, including chemotherapy with rituximab, cyclophosphamide, doxorubicin hydrochloride, oncovin, prednisolone (R-CHOP).

Open access

Boban Milovanović, Dušan Tomović, Slobodan M. Janković, Iva Grubor, Ljiljana Nikolić, Miloš Nikolić, Marina Mijajlović, Strahinja Mrvić, Ana Divjak, Andjela Milojević, Jelena Djoković, Andjelka Prokić, Andriana Bukonjić, Marija Sekulić, Vesna Matić, Djordje Vukmirović, Bojan Rakonjac, Tanja Dimitrijević, Nataša Nikolić, Dragutin Jovanović, Jelena Milovanović, Marija Ratković, Nevena Barudžić, Nenad Mladenović, Milan Milutinović, Ana Antanasković and Milena Nikolić

Summary

Fear of needles can significantly limit professional and social functioning of a person, and is highly prevalent in general population (4%).

The aim of our study was to reveal risk factors that are associated with fear of needles among healthy university students of medicine and pharmacy.

The study was of a cross-sectional type. In total, 301 students of medicine or pharmacy (82% female and 18% male) attending from 1st to 5th year of study were surveyed at the Faculty of Medical Sciences, University of Kragujevac, Serbia. The students were surveyed using a questionnaires (scales) for assessing the fear of needless, a visual analog scale for self-assessment intensity of the fear of needless, and a general questionnaire with questions about socio-demographic characteristics of the participants. Using a score on the scales as out-come variables, multiple regressions were employed to reveal factors that may influence the fear of needles.

Average values of Blood/Injection Fear Scale, Injection Phobia Scale-Anxiety and Medical Avoidance Survey scores were 7.89 ± 9.48, 4.46 ± 5.18 and 89.95 ± 12.73, respectively. The following factors affected significantly the score of the scales: course of study, chronic disease in the family, fear of a dentist, smell of the room phobia, sound phobia, score on the Beck’s anxiety scale and fear of a situation when medical staff give an injection. The presence of chronic disease in the family was a protective factor, while the other six factors were contributing to the fear of needles.

Fear of needles is more prevalent among the students of pharmacy than among the students of medicine. It is less frequent among students with chronic disease in their family, while fear of dentist, smell of the room phobia, sound phobia, general anxiety and fear from the situation when medical staff give an injection are all factors that predispose students of medicine or pharmacy to develop fear of needles.