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  • Author: Mihaela-Doina Niculescu x
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Tica Irina, Nicoară Alina-Doina, Șuța Cristina, Ghinea Mihaela-Maria, Tica Vlad-Iustin and Niculescu Zizi


Systemic Lupus Erythematosus (SLE) involves autoimmune mechanisms that affect multiple systems and has variable clinical manifestations. It affects mainly feminine gender, usually of child-bearing age. Very late onset SLE (patients older than 75 years) is rarely met and difficult to diagnose due to the unspecific symptoms. The diagnosis is frequently mistaken for drug-induced SLE or for other age-specific disorders.

We present the case of a 78 years old male patient complaining of hemoptysis in small amounts, fever, dyspnea at small efforts, weight loss, and important asthenia. Based on physical examination, severe anemia and thoracic CT aspect, several diagnosis were taken into account: anemic syndrome and pleurisy due to refractory pneumonia, pulmonary neoplasm, pulmonary tuberculosis, congestive heart failure and Wegener granulomatosis. Only when direct Coombs test came positive and all the other serological tests resulted negative, diagnosis of SLE was considered. Confirmation came along with high titers of antinuclear antibodies, anti double strained DNA antibodies and lupic anticoagulant and low levels of C3c and C4.

We conclude that the diagnosis of SLE must be taken into consideration even in elder male patients. Therapeutic options in these patients are challenging because of the associated comorbidities and side effects.

Open access

Mihaela-Doina Niculescu, Doru-Gabriel Epure, Magdalena Lasoń-Rydel, Carmen Gaidau, Mihai Gidea and Cristina Enascuta


In the present research biocomposites based on extracts of collagen and keratin recovered from the leather industry by-products were made and the specific properties for applications in agriculture and industry were studied. To this aim, collagen and keratin have been extracted from bovine leather and sheep wool by-products and have been added and crosslinked with recognized compounds for reduced environmental impact (glycerol, vegetable tanning extract, essential oils with fungicidal properties and insecticides). The biocomposite properties were evaluated on the basis of complex analytical investigations on chemical structure, texture, contact angle, mechanical resistance, water vapor permeability and water absorption, biodegradation, germination and plant biomass growth. The biocomposites have demonstrated pelliculogenic properties and nitrogen controlled release to stimulate germination and nutrition of rape seedlings, which promotes them for agricultural applications, but also other surface properties have been identified, for industrial applications, for example in leather finishing for special destinations. Addition of odorous principles with controlled release recommends this type of biocomposites for environmentally friendly products, maintenance of cleaning, etc.