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Kenzen Kou, Keishi Chin, Junichi Umemoto, Naoko Maeda, Michiru Imai, Yuuko Ikezawa, Takeshi Sasaki, Setsuko Matsukura, Michiko Aihara and Takeshi Kambara

Abstract

Background: Pyoderma gangrenosum is a rare condition usually associated with underlying diseases such as ulcerative colitis, inflammatory bowel disease, or rheumatoid arthritis. However, some cases may also be traced to trauma or surgical procedures.

Objective: We reported a patient with pyoderma gangrenosum from work-related injury with abnormal cytokine elevation.

Results: Skin biopsy of the ulcer showed diffuse cellular infiltration and increased expression of granulocyte colony-stimulating factor (G-CSF). Laboratory studies revealed elevated white blood cell levels and increases in the inflammatory markers interleukin-6 (IL-6) and G-CSF. Oral doses of prednisolone were effective in treating the ulcer.

Conclusion: Measuring G-CSF and IL-6 levels may help facilitate earlier diagnosis of pyoderma gangrenosum, thereby resulting in more effective treatment.