This article is a continuation of the Authors’ study on the ways to ensure the quality and safety of aeronautical data and information in the entire process (considered as the supply chain) of those data and information creation, collection, processing and publication. In its content attention was paid to air traffic proactive safety management aa well as the need to manage identified incompatibilities. The risk assessment and tolerability matrices arising from ICAO specifications were presented, and then on their bases, the concept of such matrices determination for aeronautical data and information chain was developed. In addition, the criteria for consequences’/effects’ of incompatibilities appearance assessment related strictly to air transport were elaborated. In the summary directions for further analysis were pointed out, leading to carrying out a full risk assessment analysis of the discussed chain with the use of the FMEA method.