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  • Author: Michał Jakub Nachajski x
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Open access

Elżbieta Nowak, Michał Jakub Nachajski and Marian Mikołaj Zgoda

Summary

Model maidenhair tree (Ginkgo bilobae) leaf extracts were created basing on medium of diversified polarity (εM). Chromatographic analysis was performed with the HPLC method, with the so-called dry residue remaining after evaporating the dissolving agent from saturated aqueous solutions and from 0.1 mol HCl. Viscosity measure and surface activity estimations were conducted on phase boundary. Then, basic values of viscosity ([η], Mη) and hydrodynamic values (Ro, Robs., Ω) were calculated. Moreover, reference quercetin and rutin (rutoside) were used to mark the conversion contents of flavonoids in produced extracts with the UV method.

Open access

Elżbieta Nowak, Zbigniew Marczyński, Beata Skibska, Michał Jakub Nachajski, Jerzy Jambor and Marian Mikołaj Zgoda

Summary

Introduction: Common ivy (Hedera helix) is a plant used successfully in the treatment of various ailments. This is possible owing to the unique set of substances contained in it such as large amount of saponins, flavonoids, phenolic acids and phytosterols as well as polyacetylenes and coumarins. All these substances have been used in the production of cosmetic and medicinal preparations. Clinical trials on the efficacy and safety of dry ivy leaf extract have shown its high efficacy, comparable to synthetic medications, and better tolerance of herbal drugs.

Objective: Investigations were performed on model ivy leaf (Hedera helix) extracts which were created using a medium of diversified polarity ( εM). Measurements of viscosity and surface activity on phase boundary were performed. During preformulation studies attention was drawn to the possibility of micellar solubilization of cholesterol and selected structures of nonsteroidal anti-inflammatory drugs (NSAIDs) – ketoprofen.

Methods: Viscosity measurements of Extractum Hederae helicis e folium aqueous solutions and in 0.1 mol HCl were performed according to the Polish Standard with Ubbelohde dilution viscometer. The surface tension of aqueous solutions -Δγsol25 of Hederae helicis e folium extracts was determined according to the Polish Standard with stalagmometric method. Critical micellar concentration (cmc) was calculated. This enabled to evaluate the dependence ΔGm0=2.303 RT×log cmc of the thermodynamic potential of micelle formation (ΔGm0 ). Results: It has been confirmed in the conducted comparative studies that aqueous solutions of Extr. Hederae helicis e folium created with maltodextrin as well as with SiO2 – maltodextrin result in micellar solubilization. The increase of granulometric size of cholesterol particle to Ø 1.60 mm decreased the amount of solubilized cholesterol but solubility preferences of the extracts were maintained.

Conclusions: Model extracts produced from Hederae helicis e folium with diversified polarity of the extraction medium (water – ethanol) are characterized by appropriate solubility of the components which results not only from the presence of chlorophyll and its derivatives in the extract but also from the technique used for spray drying of the extract.