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Open access

Rodica Török-Oance and Melania Bala’

Abstract

Background

Osteoporosis is a metabolic bone disease with a risk factor of being female, particularly after the onset of menopause.

Objectives

To evaluate the influence of age, anthropometric, and reproductive variables on spinal bone mineral density (BMD) in women with postmenopausal vertebral osteoporosis.

Methods

The study was retrospective and included data from 171 patients with postmenopausal vertebral osteoporosis. We performed both simple and multiple regressions considering BMD in spine as the dependent variable. Coefficients of correlation (r), coefficients of determination (r 2), and their level of significance were calculated.

Results

The associations between spinal BMD and each of the following variables were extremely significant: age at menarche (P = 0.0003), weight (P < 0.0001), stature (P = 0.0004), and BMI (P < 0.0001). The associations between spinal BMD and age (P = 0.004), and between spinal BMD and number of years after menopause were very significant (P = 0.0093). BMD was not associated with age at menopause or number of reproductive years. For multiple regressions there was an increasing trend of r 2 with increasing number of independent variables included in the analysis: r 2 = 21.84% (2 variables), r 2 = 24.93% (3 variables), 26.45% (4 variables), and r 2 = 27% (5 variables).

Conclusion

BMD is positively associated with weight, BMI, and stature, and is negatively associated with age, time of menarche, and years after menopause. BMD is not associated with age at menopause and reproductive period.

Open access

Mihaela Vlad, Daniela Amzar, Diana Bănică, Ioana Golu, Melania Balaș, Adrian Vlad, Romulus Timar and Ioana Zosin

Abstract

Background and Aims. Acromegaly is frequently associated with abnormalities of glucose and lipid metabolism. The aim of our study was to analyze the prevalence of glucose and lipid metabolism abnormalities in newly diagnosed acromegaly patients. Material and Methods. This retrospective study included 14 patients (F/M=10/4), mean age 49.5 ± 10.6 years, registered with acromegaly between January and December 2013. In all the cases the values of blood glucose (fasting and during the oral glucose tolerance test), total cholesterol and triglycerides were analyzed. The glucose disorders were classified according to the current criteria of the American Diabetes Association. Regarding the lipid metabolism, the cases were classified as having normal cholesterol, normal triglycerides, high cholesterol and high triglycerides. Results. A number of 7 patients (50%) presented abnormalities of glucose metabolism. The prevalence of diabetes mellitus (14.3%) was lower compared to that reported by other studies (15.5%- 56%). Abnormalities of lipid metabolism were present in 8 patients (57.2%): high cholesterol was detected in 2 cases and 6 cases presented increased values for both cholesterol and triglycerides. Only 4/14 cases (28.6%) presented normal values for all glucose and lipid metabolisms parameters. Conclusions. Abnormalities of glucose and lipid metabolisms are very common in acromegalic patients.