Marta Masternak, Joanna Knap and Krzysztof Giannopoulos
Basic hematological indices, such as platelets count (PLT), platelet distribution width (PDW), mean platelet volume (MPV), and plateletcrit (PCT), are readily accessible and commonly tested indicators. As platelets play a significant role in many physiological and patho- logical pathways, the abnormalities in these indices inference about irregularities within the organism, such as homeostatic disorders or inflammation. Recent studies revealed a significant impact of MPV on the course and prediction in different types of neoplasms. This review summarizes the most important studies on the impact of MPV levels on outcome and prognosis in different types of cancer conducted in recent years. MPV levels have a significant impact on the length of progression-free survival (PFS) and overall survival (OS) in many types of solid tumors, such as colorectal carcinoma, gastric cancer, pancreatic cancer, esophageal cancer, non-small cell lung cancer, breast cancer, and thyroid cancer. They also affect the prognosis in some lymphoproliferative diseases, such as diffuse large B-cell lymphoma, acute lymphoblastic leukemia, or primary and secondary myelofibrosis.
The results of previous studies have shown high breeding values of Beskidian spruce. The aim of the study was to assess the genetic structure of seventeen Norway spruce provenances from the Beskidy Mts. tested in IPTNSIUFRO 1964/68 experiment in Krynica, which survived after massive wind damage on the plots. Polymorphism of five isozyme systems encoded in five loci was determined. The highest value of genetic diversity parameters: mean number of alleles per locus and observed heterozygosity was noted for progeny of spruce from the Eastern Beskidy Mts. (Na = 1.47, Ho = 0.15), and the lowest - for the provenance from the Western Beskidy Mts., Babia Góra massif and the Beskid Sądecki Mts. (Na = 1.27, Ho = 0.12). Mean genetic distance between analyzed spruce provenances was equal to 0.027.