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  • Author: Mariusz Kaczmarek x
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Laboratory investigations of diclofenac migration in saturated porous media – a case study

Abstract

At present, concentrations of pharmaceuticals in surface and ground waters are low; however, even low concentrations of certain substances may prove very harmful. One of such pharmaceutical drugs is diclofenac, a popular non-steroidal anti-inflammatory drug (NSAID). For this reason, it is important to determine its mobility in groundwater and to estimate parameters of migration. Authors conducted column tests for two porous media: an artificial one, consisting of glass granules, and a natural one, i.e., sandur sand obtained from a site north of the city of Poznań (Poland). During the test, impulse breakthrough curves of chloride ions and diclofenac were recorded. The results were used to identify a specific sorption model and to determine values of migration parameters. Solutions of the inverse problem using optimisation methods and of equations of mathematical migration models were carried out in a MATLAB environment. Based on test results, the mobility of diclofenac is shown to be very high and comparable to that of chloride ions. The tests also revealed a slight and irreversible sorption of diclofenac on grains of both porous media.

Open access
Visualization of Events Using Various Kinds of Synchronized Data for the Border Guard

Abstract

STRADAR project is dedicated to streaming real-time data in a distributed dispatcher and teleinformation system of the Border Guard. The Events Visualization Post is a software designed for simultaneous visualization of data of different types in BG headquarters. The software allows the operator to visualize files, images, SMS, SDS, video, audio, and current or archival data on naval situation on digital maps. All the visualized data can be synchronized in time.

Open access
Evaluation of Neutrophils Immunophenotype in the Microenvironment of Malignant Pleural Effusions

Abstract

The lung cancer is often associated with the development of pleural effusion. Neutrophils are the most numerous population of immune system cells which are an essential component of tumor leukocyte infiltration. These cells are engaged in the development and maintenance of the inflammation. It is indicated that neutrophils support the development of cancer. The aim of the study was the evaluation of neutrophils, regarding their presence and activity in pleural effusions. This was achieved by assessing of molecular structures, which are used by neutrophils in chemotaxis and phagocytosis. 60 pleural effusions and 34 peripheral blood samples received from patients and 15 peripheral blood samples from the control group were analyzed. Expression of CD11a, CD11b, CD11c, CD18 and CD62L molecules with use flow cytometry was evaluated. The concentration of the neutrophil elastase in pleural effusions were measured with use ELISA test. The number of neutrophils in the peripheral blood of patients with pleural effusion was lower than that observed in the control group. Neutrophils present in pleural effusions were characterized by an increased ability to chemotaxis and secrete significant amounts of neutrophil elastase. Neutrophils recruited into the pleura during the formation of the effusion are an essential element of the developing inflammatory reaction in this environment. The presence of neutrophils in pleural effusion may promote its further formation and support the development of cancer.

Open access