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  • Author: Marijana Gavrilović x
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Snježana Mirković, Katarina Rajković, Sanja Jeremić, Marijana Gavrilović, Ljiljana Tomić, Valentina Arsić Arsenijević and Boro Krstić

Abstract

The objective of this paper was to assess the antiradical effectiveness of propolis extract (PE) based on 2.2-diphenyl-1-picrylhydrazyl radical (DPPH) bleaching assay kinetic profile. The kinetic profile of scavenging DPPH for PE exhibited one kinetic period characterized by one kinetic constant. The second-order rate constant (k 2) for the oxidation of PE by DPPH, determined for the first time in this study, was 0.17 dm3g−1s−1. The obtained k2 value was compared to that of synthetic antioxidants and natural extracts used in the food industry. Kinetic analysis of PE antiradical effectiveness showed that the k 2 was within the range values for natural colorants of fruit extracts and should be considered as a fast acting natural antioxidant source. The k 2 parameter indicates the extent of oxidation inhibition that is based on all of the kinetic profiles of DPPH bleaching rather than single point measurements. For this reason, the kinetic analysis should become a necessary step for more precise antioxidative characterization of propolis.

Open access

Olgica Gajović, Marijana Stanojevic-Pirkovic, Biljana Popovska-Jovicic, Ljiljana Nesic, Zeljko Mijailovic, Ivan Cekerevac, Romana Susa and Jagoda Gavrilovic

Abstract

Malaria is a potentially life-threatening disease, especially when complicated by a septic shock. It is caused by infection of erythrocytes with protozoan parasites of the genus Plasmodium that are inoculated into the humans by a feeding female anopheline mosquito. Of the four Plasmodia species, infection with Plasmodium (P.) falciparum is often associated with different types of complications and significant mortality. Most imported cases of malaria are not in tourists but in immigrants and their children who have returned to the country of their family’s origin to visit friends and relatives (so-called VFR travelers) and have forgone chemoprophylaxis.

We described a case of a 52 year old patient who came from Angola, an African country with endemic malaria before the occurrence of the first symptoms of the disease. The first symptoms were not recognized by the presence of nonspecific symptoms. Very soon the patient was gone under the hemodynamic unstability that eas followed by shock and high percentage parasitemia of 25%. A global health disorder was developed accompanied with hemodynamic instability and cerebral dysfunction. He performs pulmonary ventilation disorder and renal failure. Only data from social epidemiological survey of travel to the African country, was sufficient to cast doubt on malaria. The diagnosis was conducted using the standard method - peripheral blood smear. After turning antimalarial drugs, improvement of health status with complete recovery within 10 days was noticed. The only consequence of the disease is persistent hypertension that is sensitive to standard antihypertensive therapy.