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  • Author: Maria Bondar x
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There has been a shift in medicine from relying on clinical biomarkers to including patient-reported outcome measures. From a healthcare perspective, health-related quality of life (HRQOL) measures can be used to enhance patient care and reducing treatment cost for patients. Given the possible importance of Medical Outcome Study in medicine, and the conflicting reports in literature about its use in healthcare, it is important to identify its utility within the medical community.

In this study 150 people were recruited prospectively from patients at the Hospital and the emergency сenter №1 in Zaporizhzhya, Ukraine. Four groups were formed. The inclusion criteria to group were different comorbid pathology of osteoarthrosis. We assessed patients HRQOL SF-36 SF-36 changes before and after pharmacotherapy (over 1 year), than it were compared with the control group.

The validity of the construct has been analyzed by discriminant analysis. To assess SF-36 ability identifying discriminating functions were developed, determine its prediction value, define which scales of SF-36 are the best predictors for every groups. In addition, canonical analysis demonstrates SF-36 ability to estimate effect of pharmacotherapy.

Statistical analysis show that all indices quality of life through SF – 36 scales except of third (physical role functioning, physical functioning, emotional role functioning) have prognostic value (p>0.05) and validity of SF-39 scales for examination of the patients with coexisting disease is statistically significant(p<0.05).


Technologies for processing of digital signals find broad application in all spheres of the human activity, including agriculture. Further perfecting of these technologies is related to increasing of resolving power in analogue-to-digital and digital-to-analogue converters, requiring the improvement of quality indicator of the reference voltage sources such as noise level. This paper presents the possibilities for level reduction of output noise of the reference voltage sources. Circuit solutions of the single-stage and twostage, unipolar and bipolar low-noise sources of stable voltage of direct current produced on the basis of standard integral chips of voltage stabilizers are observed. The proposed circuit solutions provide reduction of output noise level of the reference voltage sources to the level of intrinsic noise of the operational amplifiers, which are part of the developed devices. It should be emphasized that single-stage unipolar low-noise sources of stable voltage of direct current are characteristic by the inversion of output voltage polarity that takes place in accordance with the polarity of output voltage of voltage stabilizer integral chip.