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  • Author: Mahmoud M. Mostafa x
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Novel thiophene derivatives with sulfonamide, isoxazole, benzothiazole, quinoline and anthracene moieties as potential anticancer agents

Abstract

A novel series of thiophenes having biologically active sulfonamide 2-11, 3-methylisoxazole 12, 4-methoxybenzo[d] thiazole 13, quinoline 14, 15, benzoylphenylamino 16, and anthracene-9,10-dione 17 moieties were prepared. Structures of the newly synthesized compounds were established by elemental analysis and spectral data. All newly synthesized compounds were evaluated for their in vitro anticancer activity against human breast cancer cell line (MCF7). Most of the screened compounds showed cytotoxic activities compared to doxorubicin as a positive control. Compounds 6, 7, 9 and 13 (IC50 values 10.25, 9.70, 9.55 and 9.39 μmol L-1) revealed higher cytotoxic activities than that of doxorubicin (IC50 = 32.00 μmol L-1). Also, compounds 5, 8 and 10 were found nearly as active as doxorubicin (IC50 28.85, 23.48 and 27.51 μmol L-1).

Open access
An Investigation Concerning the Effect of Canal width Contraction that May be Needed in the Location of Constructing Some Irrigation Works

Abstract

The compatibility between the needed structural designed dimensions of the irrigation works and the dimensions of the water stream or the canal in which the irrigation work will be located has a great importance from more than one point of view. As it is well known, the main aim of the designer of such works is to reach the optimum design for maximum performance efficiency with economical cost, and minimize negative technical impacts that may be harmful to the safety of the whole work. Since the complete suitability between the obtained designed dimensions of the different construction elements of the work, and the original properties and dimensions of the canal in which the work will be constructed, is rarely occurring. The designer always has to make some changes in the original engineering properties and dimensions of canals, such as bed width, bed level, and/or inside side slope, to reach the needed suitable compatibility between the structural design and the natural original canal cross section. For the economical purposes, the design always needs less width of the work, than the width of the bed of the original stream cross section, so a contraction may be needed where the work will be constructed; the literature indicated that, such a contraction must not be less than 0.6 of the original bed width. That contraction, of course, has a direct impact on the different hydraulic parameters, such as water depth, velocity, and flow regime in the location of the work. Changes of such hydraulic parameters may exceed their safe permissible values, and so the whole structure may face some dangerous situations, which must be overcome. In this paper, we present a technical survey of the previous research concerning canal width contraction, with the needed technical comments, and comparisons as a logical approach for a master-thesis under the same title.

Open access
Effect of canal width contraction on the hydraulic parameters and scour downstream water structures

Abstract

The dimensions of many water streams, which satisfy proper hydraulic conditions, may not be compatible with the designed dimensions of an irrigation work that needs to be constructed in some locations. The design requirements of such irrigation works may involve a contraction in the channel width in the required location. This contraction, of course, affects different flow properties and the scour hole formed downstream of these structures. Therefore, the present experimental study aims to investigate the effect of the transition angle and the contraction on the flow properties and on the scour phenomenon downstream water structures. Through 460 experimental runs, carried out on 20 experimental models, the study proved that, for an efficient hydraulic performance and economic design, the best transition angle (θ) for the approaches of water structures is 30° with a relative contracted width ratio (r = b/B) not less than 0.6.

Open access