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  • Author: M. Cojocaru x
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New insight into the rheumatoid vasculitis

Abstract

Vasculitis in rheumatoid arthritis (rheumatoid vasculitis, RV) has a heterogeneous clinical presentation that includes skin disorders, neuropathy, eye symptoms and systemic inflammation. Rheumatoid vasculitis is an unusual complication of longstanding, severe rheumatoid arthritis (RA).

While RA affects the body’s joints, vasculitis is a condition in which blood vessels become inflamed. Rheumatoid vasculitis occurs in approximately 2 to 5% of patients who have RA. The blood vessels most often involved are arteries that bring blood to the skin, nerves, and internal organs. Veins can also be involved. Rheumatoid vasculitis is skin condition that is a typical feature of RA, presenting as peripheral vascular lesions that are localized (purpura, cutaneous ulceration, and gangrene of the distal parts of the extremities). The cause of RV is unknown, but given the prominence of immune components and the pathologic changes in involved blood vessels, an autoimmune process is suggested. Compared to other forms of vasculitis, there has been relatively little research in recent years on the specific entity of RV. There is some evidence that the incidence of RV has decreased over the past several decades, perhaps because of a better treatment of the underlying RA. In the present review, we discuss the clinical features, laboratory tests, the pathogenesis of RV.

Open access
Multiple Intracerebral Hemorrhages in an Old Patient with Rheumatoid Arthritis

Abstract

A 78-year-old Caucasian man was admitted in the Department of Neurology for visual disturbances, started two days before. The next day the patient experienced headache, fever and gait disturbances. He had hypertension, diabetes mellitus, an ischemic stroke 13 years ago, longstanding seronegative rheumatoid arthritis (17 years), polynodular goiter, right ischio-pubian fracture and right femoral vein thrombosis a year ago due to a car accident, since he is treated with oral anticoagulants associated to antiaggregant, hypotensors, statin and oral antidiabetics. The neurologic examination had evidenced nuchal rigidity, left homonymous hemianopsia, left central facial palsy, ataxia of the inferior limbs with wide-based gait, achilean reflexes abolished bilaterally, bilaterally abolished plantar reflexes, ideomotor apraxia, dysarthria, hypoprosexia, and preserved consciousness patient. A non-contrast cerebral CT scan had shown right temporal and parieto-occipital intraparenchymatous hemorrhages, a right frontal sequelar lesion, multiple old lacunar infarcts, cortical atrophy. Laboratory findings included an inflammatory syndrome, absence of rheumatoid arthritis positive serology, normal coagulogram, an elevated proteinuria. The cerebral IRM performed on the seventh day of hospitalisation was suggestive for subacute right parietal hemorrhage, old cerebral infarction in the right anterior cerebral artery area, old lacunar infarcts and cerebral atrophy. The anticoagulant and antiaggregant treatment was stopped after a generalized tonic-clonic seizure occurred. Antiedematous, hypotensor, anticonvulsivant, beta-blocker, and symptomatic treatment was started, while the antidiabetic treatment was continued. All symptoms remitted. Arguments for amyloid angiopathy in our patient are previous non-cardioembolic ischemic stroke and a chronic inflammatory disease-rheumatoid arthritis in his personal medical history.

Open access
Lifetime Glass Reinforced Plastic Pipes by Measuring the Stiffness

Abstract

The lifetime of glass reinforced plastic pipes is 50 years. Extensive use of this type of pipe in its various applications, led to investigate their behavior in land that anthropogenic or natural causes, shows the different values of pH to neutral. The paper presents experimental results conducted on three samples of a PN SN10000 DN150 PN10 pipe buried in three different types of terrain: neutral, acidic, basic. They were subjected to axial load, measuring the force applied deformation force function. On the basis of the calculation formulas determined rigidity of the pipeline, the deformation speed of 50 mm / min. This concludes the type of land affects the rigidity of the pipe so its length of life decreases to that provided by suppliers in order to be taken compensatory measures in this regard such as choosing a higher class of pressure and stiffness pipeline than those arising discounted. This will allow for long-term value (50 years) in the mechanical characteristics sufficient for safe operation.

Open access
Experimental Evaluation a Tensile Strength of PAFSIN Pipes in Different Types of Land

Abstract

Most studies on the PAFSIN pipes were oriented monitoring their behavior in laboratory conditions, focusing on the fluid and less influence on the environment laying on the mechanical properties in the short term then extrapolated mathematical term. Moreover, a large part of these studies refer only to the effect on PAFSIN composite samples without taking into account the specificities induced specific geometry pipeline. In this way, the effect PAFSIN pipes can be overlooked, which in practice can lead to significant errors of design and / or execution. Compared to existing studies, taking into account only the effect of a sealant (generally standardized solutions of acid or base) of the PAFSIN pipes, in the article to present the results of tests conducted on PAFSIN pipes buried in different types of land and attempted to surprise the complexity of the interactions of soil solution to the conduit.

Open access