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M. Basińska

Abstract

The goal of this paper was to optimize the building envelope and technical equipment in the building through the mitigation of the global cost value, and then to evaluate the influence of the chosen assumptions on the primary energy index. The analyses carried out using global cost method allow for finding the cost optimal solution but only for the some range of primary energy index variability. In order to find the optimal solutions it was proposed to use the multi-criteria optimisation, assuming the following as basic criteria: a global cost value and investment prices increase (economic criteria), a primary energy index (energy-related criterion), an emission of carbon dioxide (environmental criterion). The analysed case study refers to the technical solutions for the residential buildings with the usable energy demand at the level of 40 and 15 kWh/m2/a. The presented method might be applied to different types of buildings: those being designed and those being the subject of the thermo-modernisation. The results demonstrate that the proposed model allows for classification of the alternative technical solutions regarding the designing process and the building’s technical equipment. The carried out analyses indicate the economic possibility to achieve the low energy building standard and show the need to concentrate the activities related to the installation technology and used energy source.

Open access

J. Nicpoń, A. Siudzińska, M. Marędziak, A. Śmieszek, K. Basińska and M. Koszykowska

Abstract

The influences of NSAIDs (Nonsteroidal Anti-inflammatory Drugs) – non-selective metamizole and selectively-acting tolfenamic acid were estimated on morphology, ultrastructure, and cytophysiological activity of canine (Ca) and equine (Eq) adipose-derived mesenchymal stem cells (ASCs). The lowest concentration of metamizole (0.01 mg/mL) stimulated the viability and cytophysiological activity of Ca ASCs and did not affect cell morphology. Stimulated cells possessed a proper, fibroblastic shape, with large, eccentrically located nuclei. Similar effects to those observed in Ca ASCs were found in Eq cells treated with both drugs. Cells cultivated with the intermediate (0.1 mg/mL) doses of NSAIDs displayed proper cell morphology, whereas cells cultivated in intermediate dose (0.1 mg/mL) became more flattened. The highest concentrations (1 mg/mL) of both drugs resulted in a cytotoxic effect in Ca and Eq ASCs. Based on these results, we conclude that stimulation of Ca and Eq ASCs with metamizole as well as Eq ASCs with tolfenamic acid can lead to positive effects only when the lowest drug concentrations are applied. This study indicates a different cellular response of canine and equine ASCs treated with metamizole and tolfenamic acid. The obtained data might be potentially useful in the study of functionalized veterinary biomaterials.