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Mária Kiššová

Abstract

One of the most fundamental questions in the discourse on artistic creativity and interpretation is that of mimesis or representation; the relation and the ‘tension’ between experiential reality on one hand and an artistic construct on the other hand. In the present study, mimesis and the discussion about the connection between the experiential and the imaginary are understood as major characteristics by which man and the human condition are defined. From the context of the visual arts, the study proceeds to literature and, specifically, to an analysis of the novel The Real Life of Sebastian Knight (1941) by Vladimir Nabokov (1899-1977). The main aim of the study is to show the questions of representation and interpretation as part of the universal inquiry about humanity and the human condition.

Open access

Maria Goboova, Magdalena Kuzelova, Viera Kissova, Dasa Bodakova and Elena Martisova

Abstract

Augmented renal clearance (ARC) is a recently reported condition in pathophysiology of critically ill patients in the intensive care unit. ARC refers to the enhanced renal elimination of circulating solutes. These patients are either young or previously healthy people who have undergone surgery or multiple trauma.

This case report describes an adjustment of dosing regime of vancomycin to a young patient, who demonstrated ARC with severe polytrauma, overcome crush syndrome and sepsis. This 16-year old male patient was crushed by a tractor, which caused severe tissue damaged in the right lower limb. He gradually developed a serious crush syndrome. When kidneys resumed their function, creatinine clearance reached the value that indicated ARC (339.81 mL/min/1.73 m2). Vancomycin was included in the patient’s treatment regime by administering conventional dose of 1 g per 12 hours. The residual measured levels were very low. The dose of vancomycin had to be adjusted to double and then to triple the conventional dose. Without the therapeutic drug monitoring (TDM) and subsequent interpretation of the results by the clinical pharmacists, such high doses would not have been considered for administration.

ARC responds strongly to sub-therapeutic serum vancomycin levels. Our case report confirms the significance of TDM and the consecutive interpretation of the results in critically ill patients.

Open access

Mária Kiššová and Ľubomír Ščerbák

Abstract

The study focuses on the short prose text Imagination Dead Imagine (1965) by the Irish writer Samuel Beckett (1906-1989). It argues that while at first sight Beckett’s text appears to be a chaotic verbal blend with no coherence, a close reading discloses an actual underlying pattern (mandala) which gives the text a structure and enables the reader to “understand” it. The authors of the paper claim that mandala, as the structural pattern of the text, represents an attempt to find a resolution of the existential and universal conflict within man. On one hand, there is spiritual alienation (exemplified here by the dissolution of the language) and, on the other hand, one’s desire to be integrated with unity and return to the centre