Search Results

You are looking at 1 - 1 of 1 items for

  • Author: Lucia Corrado x
Clear All Modify Search
Open access

Letizia Mazzini, Fabiola De Marchi, Lucia Corrado and Sandra D’Alfonso


Amyotrophic lateral sclerosis, also known as motor neuron disease or Lou Gehrig’s disease, is an adult-onset neurodegenerative disease that targets motor neurons in the spinal cord, cortex and brain stem. Selective degeneration of corticospinal (upper) and spinal (lower) motor neurons manifests as a linear decline in muscular function, eventually resulting in paralysis, speech and swallowing deficits and death, usually from impaired respiratory function, over a time course of approximately 3-5 years.