Objective To observe the therapeutic effects of intraperitoneal injection of antibiotics, intravenous injection of terlipressin, and combined treatment of coloclysis and plasma exchange on hepatic failure(HF), the subjects included 494 inpatient cases of hepatic failure who were treated in Department of Infectious Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China from 1997 to 2008.
Methods The patients that met the inclusion criteria were divided into intraperitoneal antibiotic injection group, intravenous terlipressin injection group, coloclysis group, plasma exchange group, combination group of coloclysis and plasma exchange in terms of treatment given and a control group was set up for each of the treatment group. In the intraperitoneal injection group, the prognosis and changes in clinical manifestations were observed in HF patients complicated with spontaneous peritonitis (SBP). In terlipressin injection group,HF patients complicated with hepatorenal syndrome (HRS) were observed for prognosis and changes in serum creatinine. In the combination group, the improvement in serum total bilirubin and prothrombin activity were observed.
Results Two weeks after intraperitoneal injection of antibiotics, the ease ratios of abdominal pain, pressure pain and rebound tenderness were 87.64%, 82.02% and 82.02% in the intraperitoneal injection group, respectively and the volume of ascites obviously decreased in 69 patients (77.53%). The survival rate in intraperitoneal injection group was significantly higher than in control group (P ＝ 0.004). Four to eight days after the intravenous injection of terlipressin, the survival rate and the rate of serum creatinine decline of the treatment group were significantly higher than those in the control group (P ＝ 0.003, P ＝ 0.000). After 4 weeks of treatment, the ratio of clinical symptoms improvement (acratia, anorexia, abdominal distension, constipation) in coloclysis group were 60.27%, 57.53%, 91.78% and 94.52%, in plasma exchange group were 71.83%, 69.44%, 75% and 72.22%, and in combination group were 82.14%, 79.46%, 92.85% and 95.54%. The serum total bilirubin was decreased and the prothrombin activity increased and the differences were statistically significant as compared with control group (P ＝ 0.000).
Conclusions The intraperitoneal injection of antibiotics, intravenous injection of terlipressin and combined treatment of coloclysis and plasma exchange were all effective for the treatment of HF and its complications.