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  • Author: Liang Chen x
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Knowledge Representation in Patient Safety Reporting: An Ontological Approach



The current development of patient safety reporting systems is criticized for loss of information and low data quality due to the lack of a uniformed domain knowledge base and text processing functionality. To improve patient safety reporting, the present paper suggests an ontological representation of patient safety knowledge.


We propose a framework for constructing an ontological knowledge base of patient safety. The present paper describes our design, implementation, and evaluation of the ontology at its initial stage.


We describe the design and initial outcomes of the ontology implementation. The evaluation results demonstrate the clinical validity of the ontology by a self-developed survey measurement.

Research limitations

The proposed ontology was developed and evaluated using a small number of information sources. Presently, US data are used, but they are not essential for the ultimate structure of the ontology.

Practical implications

The goal of improving patient safety can be aided through investigating patient safety reports and providing actionable knowledge to clinical practitioners. As such, constructing a domain specific ontology for patient safety reports serves as a cornerstone in information collection and text mining methods.


The use of ontologies provides abstracted representation of semantic information and enables a wealth of applications in a reporting system. Therefore, constructing such a knowledge base is recognized as a high priority in health care.

Open access
LncRNA: An all-rounder in rheumatoid arthritis


Rheumatoid arthritis (RA) is a chronic autoimmune disease and is supposed to have both genetic and environmental backgrounds. Plenty of studies have demonstrated the roles of long non-coding RNAs (lncRNAs) in the initiation and development of RA. Numerous lncRNAs have been found to be dysregulated in RA and to be correlated with disease activity of RA, which indicates potential diagnostic roles of lncRNAs. In addition to working as biomarkers for RA, lncRNAs participate in many specific pathological processes including inflammation, aberrant proliferation, migration, invasion and apoptosis. Further screenings and researches are required to validate the clinical potentials of lncRNAs as diagnostic and therapeutic targets in RA.

Open access
Synthesis, sintering, specific heat and magnetism of Eu3S4 by low-temperature CS2-gas sulfurization of Eu2O3 nanospheres


Single-phase Eu3S4 was obtained via CS2 gas sulfurization of Eu2O3 nanospheres at 773 K for longer than 0.5 h. The primary particle size of Eu3S4 became larger than that of Eu2O3 during the sulfurization process. Pure synthetic Eu3S4 powders were unstable and transformed to EuS at 873 K under vacuum. Eu3S4 compacts were sintered in temperature range of 773 K to 1173 K and they transformed to EuS at 1473 K during spark plasma sintering. Specific heat of sintered Eu3S4 did not show an anomalous behavior in the range of 2 K to 50 K. The magnetic susceptibility of polycrystalline Eu3S4 followed a Curie-Weiss law from 2 K to 300 K. Magnetization of polycrystalline Eu3S4 was larger than that of single crystal Eu3S4 when the magnetic field was less than 3.5 kOe.

Open access
Lower left lung abscess from combined stomach and left diaphragm perforation by an intragastric foreign body


Background: Usually children mistakenly swallow foreign bodies, and most objects are spontaneously discharged through the digestive tract without consequence. However, sometimes the objects can cause gastrointestinal perforation, with serious complications.

Objective: To report the case of a 26-year-old male patient, who mistakenly swallowed a bamboo chopstick 14 years ago. The chopstick eventually perforated the gastric fundus and left diaphragm, pierced the lower left lobe of the lung, and caused a lower left lung abscess.

Method: A thoracotomy was conducted to remove the foreign body and the lower left lobe of the lung, followed by a patch fundoplication.

Result: The object was removed and the patient’s lesions healed after surgery.

Conclusion: The ingestion of foreign bodies rarely causes serious problems, but we should be vigilant to the occurrence of complications, and close follow-up should be conducted. This follow-up should include confirmation that the foreign body has passed through the alimentary tract.

Open access
Performance Degradation Assessment of Rolling Element Bearings using Improved Fuzzy Entropy


Rolling element bearings are an important unit in the rotating machines, and their performance degradation assessment is the basis of condition-based maintenance. Targeting the non-linear dynamic characteristics of faulty signals of rolling element bearings, a bearing performance degradation assessment approach based on improved fuzzy entropy (FuzzyEn) is proposed in this paper. FuzzyEn has less dependence on data length and achieves more freedom of parameter selection and more robustness to noise. However, it neglects the global trend of the signal when calculating similarity degree of two vectors, and thus cannot reflect the running state of the rolling element bearings accurately. Based on this consideration, the algorithm of FuzzyEn is improved in this paper and the improved FuzzyEn is utilized as an indicator for bearing performance degradation evaluation. The vibration data from run-to-failure test of rolling element bearings are used to validate the proposed method. The experimental results demonstrate that, compared with the traditional kurtosis and root mean square, the proposed method can detect the incipient fault in advance and can reflect the whole performance degradation process more clearly.

Open access
Research on high-temperature compression and creep behavior of porous Cu–Ni–Cr alloy for molten carbonate fuel cell anodes


The effect of porosity on high temperature compression and creep behavior of porous Cu alloy for the new molten carbonate fuel cell anodes was examined. Optical microscopy and scanning electron microscopy were used to investigate and analyze the details of the microstructure and surface deformation. Compression creep tests were utilized to evaluate the mechanical properties of the alloy at 650 °C. The compression strength, elastic modulus, and yield stress all increased with the decrease in porosity. Under the same creep stress, the materials with higher porosity exhibited inferior creep resistance and higher steadystate creep rate. The creep behavior has been classified in terms of two stages. The first stage relates to grain rearrangement which results from the destruction of large pores by the applied load. In the second stage, small pores are collapsed by a subsequent sintering process under the load. The main deformation mechanism consists in that several deformation bands generate sequentially under the perpendicular loading, and in these deformation bands the pores are deformed by flattering and collapsing sequentially. On the other hand, the shape of a pore has a severe influence on the creep resistance of the material, i.e. every increase of pore size corresponds to a decrease in creep resistance.

Open access
Nonlinear PTO Effect on Performance of Vertical Axisymmetric Wave Energy Converter Using Semi-Analytical Method


The wave energy, as a clean and non-pollution renewable energy sources, has become a hot research topic at home and abroad and is likely to become a new industry in the future. In this article, to effectively extract and maximize the energy from ocean waves, a vertical axisymmetric wave energy converter (WEC) was presented according to investigating of the advantages and disadvantages of the current WEC. The linear and quadratic equations in frequency-domain for the reactive controlled single-point converter property under regular waves condition are proposed for an efficient power take-off (PTO). A method of damping coefficients, theoretical added mass and exciting force are calculated with the analytical method which is in use of the series expansion of eigen functions. The loads of optimal reactive and resistive, the amplitudes of corresponding oscillation, and the width ratios of energy capture are determined approximately and discussed in numerical results.

Open access
Comparison between cryoablation and irreversible electroporation of rabbit livers at a location close to the gallbladder



The ablation of liver tumors located close to the gallbladder is likely to lead to complications. The aim of this article is to compare the safety and efficacy of irreversible electroporation (IRE) and cryoablation in rabbit livers at a location close to the gallbladder.

Materials and methods

We performed cryoablation (n = 12) and IRE (n = 12) of the area of the liver close to the gallbladder in 24 New Zealand white rabbits in order to ensure gallbladder damage. Serum aminotransferase and serum bilirubin levels were measured before and after the ablation. Histopathological examination of the ablation zones in the liver and gallbladder was performed on the 7th day after the ablation.


Seven days after the ablation, all 24 animals were alive. Gallbladder perforation did not occur in the IRE group; only mucosal epithelial necrosis and serous layer edema were found in this group. Gallbladder perforation occurred in four rabbits in the cryoablation group. Serum aminotransferase and serum bilirubin levels obviously increased in both groups by Day 3 and decreased gradually thereafter. The elevation in aminotransferase and bilirubin levels was greater in the cryoablation group than the IRE group. Pathological examination revealed complete necrosis of the liver parenchyma from the ablation center to the gallbladder in both groups, but bile duct and granulation tissue hyperplasia were observed in only the IRE group. Full-thickness gallbladder-wall necrosis was seen in the cryoablation group.


For ablation of the liver area near the gallbladder, IRE is superior to cryoablation, both in terms of safety (no gallbladder perforation in the IRE group) and efficacy (complete necrosis and rapid recovery in the IRE group).

Open access