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  • Author: Li-quan Dong x
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Hui Li, Xiao-Dong Yang, Yong-Rui Yang, Si-Yuan Gao, De-Ying Tian and Quan Yuan

Abstract

Background and Aims Recently, epidemiology studies of hepatitis E in different areas are attracted more attention. Extensive studies of prevalent status and clinical manifestations could help us to broaden our knowledge, so as to excellently prevent and treat hepatitis E. The study analyzed the epidemiological characteristics and clinical features of 394 cases of sporadic acute hepatitis E (AHE) in Southwest of China from 2008 to 2010.

Methods The clinical data of 394 cases with sporadic AHE in Southwest of China from 2008 to 2010 were reviewed.

Results In the 394 cases with sporadic AHE, the ratio of male/female was 1.432 : 1, and the mean age was (31.53 ± 18.12) years. Totally, 94 (23.86%) patients aged under 18, 271 (68.78%) patients aged between 18 and 60, and 29 (7.36%) patients aged above 60. The incidence rate was significantly increased in summer (P = 0.000), especially in May (14.72%) and July (13.71%). In addition, the characteristics of occupation and ethnic group distribution were migrant laborers (106/394, 26.90%) and Han people (365/394, 92.64%). The length of stay, incidence of jaundice, the peak value of total bilirubin and alanine aminotransferase in male patients were all higher than those in female patients significantly (P < 0.05). The prolonged length of stay, decreased levels of ALT/ALB/CHE, increased levels of TBil, and increased incidence of jaundice and fatigue were associated with older age significantly (P < 0.05). The differences in peak values of total bilirubin (TBil), total bile acid (TBA), glutamyltransferase (GGT), cholinesterase (CHE) between AHE group and the groups of AHE accompanied respectively by chronic hepatitis B (CHB), acute alcoholic fatty liver (AFL), nonalcoholic fatty liver disease (NAFLD) were significant (P < 0.05). In addition, no significant difference was found in length of stay and biochemical indexes among anti-HEV-IgG positive group, anti-HEV-IgM positive group and anti- HEV-IgM/IgG both positive group (P > 0.05).

Conclusions Four epidemiological characteristics, including aged between 18 and 60, male, summer and migrant laborers, are found to be associated with acute hepatitis E. The prognosis of AHE in the majority of patients was favorable, but aged above 60 years and coexistence with CHB, AFL and NAFLD could be considerede as the factors inducing the infaust prognosis.

Open access

Yu Dai, Quan-yang Ma, Xiao-hua Li, Xi Zhang, Fa-ping Hu, Yun Zhang and Wei-dong Xie

Abstract

In this paper, crushability of foundry sand particles was studied. Three kinds of in-service silica sands in foundry enterprises selected as the study object, and foundry sand particles were subjected to mechanical load and thermal load during service were analyzed. A set of methods for simulating mechanical load and thermal load by milling and thermal-cold cycling were designed and researched, which were used to characterize the crushability for silica sand particles, the microstructure was observed by SEM. According to the user’s experience in actual application, the crushability of Sand C was the best and then Sand B, the last Sand A. The results indicated that mechanical load, thermal load and thermal-mechanical load can all be used to characterize the crushability of foundry sand particles. Microscopic appearances can qualitatively characterize the crushability of foundry sand particles to a certain extent, combining with the additions and cracks which are observed on the surface.