In this research, the effect of the European regional differences on the risk of been killed in road accident in these regions is investigated. Factors which differentiate regions can be described as automotive, economic, infrastructural, demographic, geographic. Analyzed risk, counted as regional fatality rate was modeled by the Poisson model. Because of regional diversity of Poisson distribution parameters, the Poisson distribution was adopted. The multivariate multilevel model was developed, in order to asses combined effects of different factors on road safety level in regions. Such models could be helpful to forecast such risk on the regional level and focus safety actions precisely for region, because the national actions and their results differentiate in regions so far.