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  • Author: L. Muflic x
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Renal disease in patients with rheumatoid arthritis treated with biological therapy

Abstract

The use of biological therapies may have positive impact on chronic renal disease associated with rheumatoid arthritis.

The study evaluates retrospectively renal function in 57 patients with rheumatoid arthritis treated with different types of biological therapy, comparative with 62 RA patients treated conservatively with DMARDs.

Patients treated with biological therapies presented a lower mean value for serum creatinine measured both at baseline and after 6 months of treatment, statistically significant compared with the subgroup treated with DMARDs (0.69 ± 0.17 mg/dL vs. 1.18 ± 1.01 mg/dL, p = 0.003). Results for estimated filtration rate were significantly increased in biologically treated cohort (100.36 ± 16.76 mL/min/1.73 m2 vs. 63.49 ± 21.60 mL/min/1.73 m2, p < 0.00001). Rituximab presented a better estimated filtration rate compared with other biological tharapies (eGFR 97.037 mL/min/1.73 m2 vs. 90.933 mL/min/1.73 m2).

The positive effect of potent biological anti-inflammatory therapies sustains the need of further exploring the risk of reduced kidney function in immune-mediated diseases, including rheumatoid arthritis.

Open access
Acute myocardial infarction with multiple mechanical complications

Abstract

The rupture of the inter-ventricular septum is a rare, but extremely severe mechanical complication of the acute myocardial infarction, which in most cases of no immediate surgery is fatal (30 days death rate – 80%). The incidence of the septum ventricular defect post-acute myocardial infarction was 1-3% in the period before crash injury therapy, dropping to 0.2% after introducing the thrombolytic treatment.

The acute mitral failure and the septum ventricular defect are two mechanical complications of the acute myocardial infarction associated with high death rate, regardless of the progress made in medical and surgery therapeutic approach.

This paper highlights the peculiarities of a clinical case like the acute myocardial infarction as the first manifestation of heart disease in a patient with no history of cardiovascular disease but with risk factors (obesity, dyslipidemia, hypertension), the ECG evident changes in the anterior territory and more discrete in the inferior territory, which established the initial diagnosis to be myocardial infarction and the presence of two mechanical threatening complications: ventricular septal flaw and acute mitral failure through posterior papillary muscle incomplete rupture.

Open access
A real health problem of our days: Colorectal Cancer

Abstract

Colorectal cancer is one of the major mortality causes in the world, with an increased frequency in western countries, which are better developed economically. Romanian statistics show that the frequency of this type of cancer is increasing rapidly. In the year 2000, all over the world there were approximately 1 million new cases of colorectal cancer, and over 500 thousands deaths, thus affecting 1 from 20 inhabitants from the developed countries and being the second main cancer death cause, at both sexes in Europe. In Romania, incidence and mortality have doubled in the last 20 years, reaching a 17.74/100000 inhabitants incidence in the year 2000. Both for men and women, this disease is on the 3rd place in Romania, after bronhopulmonary cancer and gastric (for men) and breast and uterus cancer, respectively.

This paper has as purpose obtaining data about the frequency of colorectal cancer in recent years, and the repartition of this data on years, sex, age, environment, complications and other particularities. To reach this purpose we have done a retrospective study on patients that were admitted during 2010-2014 in the surgical clinic, medical clinic and oncology section from the Constanta Emergency County hospital, with colorectal neoplasm as a diagnosis.

Open access
A real health problem of our days: Colorectal Cancer

Abstract

Acute pancreatitis represents the acute inflammatory process of the pancreas which can remain localized in the gland or could extend in the tissues around the pancreas or retroperitoneal tissues and also at the organs from the pancreatic lodge.

The diagnosis is usually based on the increase in pancreas volume and on the changes in structure objected on the ultrasound examination. It is characterised by a “release” of enzymes out of the pancreatic ducts associated with oedema and necrosis in the parenchyma and in the retroperitoneal area.

Open access