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Open access

Mei Li, Mei Wang, Shouhai Li, Kun Huang, Wei Mao and Jianling Xia

Abstract

Calcium and zinc salts of dimer fatty acids (DFA-Ca and DFA-Zn) were synthesized using direct neutralization and metathesis technologies, respectively. The adduct of maleic anhydride and methyl eleostearate (MAME) was also converted to the corresponding zinc soap (C22TA-Zn) and calcium soap (C22TA-Ca) by the two different synthetic routes. Mixed Ca/Zn salts between DFA-Ca and DFA-Zn, and between C22TA-Zn and C22TA-Ca were used as thermal stabilizers for poly(vinyl chloride) (PVC). The PVC thermal stability was determined using Congo red test, discoloration test, torque rheological analysis and TGA. Dynamic mechanical properties were also tested. Results indicated that the DFA-Ca/DFA-Zn thermal stabilizer from direct neutralization technology was found to be superior to that of the metathesis product. The C22TA-Ca/C22TA-Zn thermal stabilizer from direct neutralization method had overall superior thermal stability, and displayed modulus and glass transition comparable to that of metathesis product. Direct neutralization method was more excellent and convenient than metathesis technology.

Open access

Xiao-Jing Guo, Li-Li Wei, Xin-Hui Li, Ning- Ning Yu, Shao-Bo Gao, Dong-Yan Qin, Fu-Mei Chu and Kun Li

Abstract

Objective

The aim of this study was to explore the safe and effective method of expectoration in the preoperative period of patients with lung cancer resection and to promote the rehabilitation of patients.

Methods

A total of 100 cases of lung cancer patients undergoing elective surgery were divided into the observation group and the control group, with 50 cases in each group. The control group was treated with vibration expectoration vest for expectoration during the perioperative period, and the observation group was treated with respiratory function exerciser that has expectoration function in the perioperative period, three times a day, and the effect was evaluated after 5 days.

Results

The number of patients in the observation group after the first expectoration time was significantly less than that of the control group (P<0.001). Pain score, pulmonary atelectasis, and pulmonary infection rate of the observation group were significantly lower than those of the control group; the hospitalization time was significantly shorter than that of the control group; and the difference was statistically significant (P<0.05).

Conclusions

Lobectomy for lung cancer patients with perioperative respiratory training for respiratory function exercise, compared with conventional methods, is helpful for postoperative expectoration and to reduce the incidence of adverse events.

Open access

Ai-kun Ding, Li-wei Guo, Yong-kong Wang, Wei Liu, Cheng Li and Chang-yuan Wang

Abstract

Objective To study the mutual relationship between anti-HBx and IL-10, IL-12 or soluble Fas (sFas) in sera of patients with chronic HBV infection and to explore the importance of anti-HBx detection as well as its role in the development of chronic HBV infection.

Methods Total of 90 cases with chronic HBV infection were randomly selected, including 10 of asymptomatic carriers (ASC), 28 of chronic hepatitis B (CHB), 26 of liver cirrhosis (LC) and 26 patients of hepatocellular carcinoma (HCC). Their clinical data and blood samples were collected, and serum was prepared and stored at -73℃. Anti-HBx was detected with an indirect ELISA established in our earlier research, and levels of IL-10, IL-12 and Fas were determined with commercial double-antibody sandwich ELISA kits. The mutual relationship between anti-HBx and IL-10, IL-12 or sFas in serum were analyzed with the software SPSS 20.0.

Results All levels of IL-10, IL-12 and sFas in peripheral blood showed a rising trend with development of chronic HBV infection. The levels of IL-10 in ASC, CHB, LC and HCC groups were 13.93 ± 14.40 ng/L, 39.38 ± 20.77 ng/L, 69.06 ± 46.37 ng/L and 62.82 ± 23.42 ng/L, respectively, levels of IL-12 in the 4 groups were 15.64 ± 23.04 ng/L, 68.50 ± 23.14 ng/L, 76.83 ± 12.82 ng/L and 83.74 ± 24.88 ng/L, respectively, and levels of sFas were 58.17 ± 77.42 ng/L, 179.88 ± 104.36 ng/L, 249.22 ± 107.80 ng/L and 252.98 ± 87.65 ng/L, respectively. Twenty-seven out of 90 patients showed a positive result for anti-HBx detection, including 1 in ASC, 4 in CHB, 12 in LC and 10 in HCC group. The levels of IL-10, IL-12 and sFas were higher in anti-HBx positive group than in negative group. Statistical analysis demonstrated significant differences of IL-10 and IL-12 between the two groups (P < 0.05), but the differences of sFas had no statistical significance (P = 0.094).

Conclusions Anti-HBx antibody is not protective, and is closely related to IL-10, IL-12 and sFas. It may be an important serum indicator for aggravation from chronic hepatitis B to liver cirrhosis or hepatocellular carcinoma in patients with chronic HBV infection.

Open access

Wei Mao, Shouhai Li, Mei Li, Kun Huang and Jianling Xia

Abstract

A novel bio-based flame-retardant thermosetting vinyl ester resin monomer was synthesized from castor oil. The chemical structures of the monomer was characterized by FTIR and 1H-NMR. In order to improve its rigidity and expand its application in the field of bio-based materials, it was mixed with certain proportions of another reactive bio-based VER monomer, which had rigid and strong polar groups, and then a series of copolymers were prepared with thermal curing method. Then their tensile property, hardness, morphology of fractured surface, flame retardant property, DMA and thermostability were all investigated. The results indicated that the copolymers had relatively high tensile strength of 11.2 MPa, and the limiting oxygen index is above 23% in all prepared copolymers. DMA demonstrates that the glass transition temperature of the cured resins is up to 56.1°C. Thermogravimetric analysis shows that the copolymers have excellent thermal stability.

Open access

Yongjiang Luo, Lijia Li, Jianming Peng, Kun Yin, Peng Li, Xin Gan, Letao Zhao and Wei Su

Abstract

The subterranean cavities are seriously threatened to construction and mining safety, and it’s important to obtain the exact localization and dimensions of subterranean cavities for the planning of geotechnical and mining activities. Geophysical investigation is an alternative method for cavity detection, but it usually failed for the uncertainly solution of information and data obtained by Geophysical methods. Drilling is considered as the most accurate method for cavity detection. However, the conventional drilling methods can only be used for single cavity detection, and there is no effective solution for multilayer cavities detection have been reported. In this paper, a reverse circulation (RC) down-the-hole (DTH) air hammer system with a special structured drill bit is built and a cavity auto scanning laser system based on laser range finding technique was employed to confirm the localization and dimensions of the cavities. This RC-DTH air hammer system allows drilling through the upper cavities and putting the cavity auto scanning laser system into the cavity area through the central passage of the drill tools to protect the detection system from collapsing of borehole wall. The RC-DTH air hammer system was built, and field tests were conducted in Lanxian County Iron Ore District, which is located in Lv Liang city of Shan Xi province, the northwest of china. Field tests show that employing the RC-DTH air hammer system assisted by the cavity auto scanning laser system is an efficiency method to detect multilayer cavities.

Open access

Yu-Li Su, Shan-Hsuan Li, Yen-Yang Chen, Hui-Chun Chen, Yen Tang, Cheng-Hua Huang, Fong-Fu Chou, Shih-Chung Wu and Kun-Ming Rau

Abstract

Background. To determine the role of postmastectomy radiotherapy (PMRT) in breast cancer patients with T1-2 and N1 disease.

Patients and methods. A total of 207 postmastectomy women were enrolled. The 5-year Kaplan-Meier estimates of locoregional recurrence rate (LRR), distant recurrence rate (DRR) and overall survival (OS) were analyzed by different tumor characteristics. Multivariate analyses were performed using Cox proportional hazards modeling.

Results. With median follow-up 59.5 months, the 5-year LRR, DRR and OS were 9.1%, 20.3% and 84.4%, respectively. On univariate analysis, age < 40 years old (p = 0.003) and Her-2/neu over-expression (p = 0.016) were associated with higher LRR, whereas presence of LVI significantly predicted higher DRR (p = 0.026). Negative estrogen status (p = 0.033), Her-2/neu overexpression (p = 0.001) and LVI (p = 0.01) were significantly correlated with worse OS. PMRT didn’t prove to reduce 5-year LRR (p = 0.107), as well as 5-year OS (p = 0.918). In subgroup analysis, PMRT showed significant benefits of improvement LRR and OS in patients with positive LVI.

Conclusions. For patients with T1-2 and N1 stage breast cancer, PMRT can decrease locoregional recurrence and increase overall survival only in patients with lymphovascular invasion.

Open access

Xiaoxiao Han, Rongsheng Zhou, Wei Zheng, Xitao Wang, Shuyan Mao, Zhenbei Li, Lin Hao, Zhenduo Shi, Bo Chen, Zhiguo Zhang, Yijuan Cao, Dianjun Yu, Kun Pang and Conghui Han

Abstract

Aim: The aim of the study is to investigate the effect of Cynomorium songaricum (CS) on the damage caused by cyclophosphamide (CP) in SD rats. Methods: Rats with CP-induced oligoasthenospermia were treated with different concentration of CS. Testicle weight, epididymal sperm count (ESC), sperm motility, and serum testosterone were analyzed, and expression levels of Thy1, Oct4, PLZF, C-kit, and GDNF were detected in testis tissues. Transmission electron microscopy (TEM) was performed to observe the effect of CS on the spermatogenic damage by CP. Results: Compared with the CP group, there were significant differences in testicle weight, ESC, and sperm motility (p<0.05) observed in all concentrations of CS and CP+VitE groups (p<0.05). There were no significant differences in serum testosterone among the 6 groups (p>0.05). The qPCR results revealed a significant difference in Thy1, Oct4, PLZF and GDNF expression between the CP group and CS group (p <0.05), but there was no significant difference in C-kit between the two groups (p>0.05). The damage of CP was cured by CS observed under TEM. Conclusion: CS can increase sperm counts in the epididymis and improve sperm motility and has a therapeutic effect on the spermatogenic damage caused by CP in SD rats.