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Open access

Fatemeh Paknazar, Mahmood Mahmoudi, Kazem Mohammad, Hojjat Zeraati, Mohammad Ali Mansournia and Mehdi Yaseri

Abstract

Background

Following treatment, cancer patients may be clinically cured. However, they may die for reasons other than cancer, called competing risks.

Objective

To estimate postoperative cure while considering the competing risks in Iranian patients with gastric cancer.

Method

Data were obtained from the Cancer Institute of Imam Hospital in Tehran. The analysis was conducted within the framework of relative survival by fitting the data to a flexible parametric cure model, taking into account the competing risks using general population data by adjusting for age, sex, and year of diagnosis.

Results

Of the 326 patients (224 male and 102 female) whose data were included, 235 deaths (72.1%) occurred during the follow-up period. The probability of conditional cure in terms of crude ratios of dying from causes other than gastric cancer in the surviving patients increased with the passage of time, and the slope of excess mortality approached almost 0 after 7 years. The estimated cure ratios showed a variation from 69% for 50-year-old men with diagnosis at early stages (I and II) to 3% for 80-year-old women with diagnosis at stage IV.

Conclusion

The ratio of patients in Iran who were estimated to die from cancer reduced significantly with the passage of time following the diagnosis, and the statistical cure point was estimated to be 7 years after diagnosis. However, aging was shown to be inversely associated. Although the same trend was observed in both sexes, we showed that men were statistically more likely to reach the cure point.

Open access

Fatemeh Amin, Mohammad Mehdi Jahani, Hamid Ghaedi, Behnam Alipoor, Ahmad Fatemi, Michael Tajik, Zohreh Sharifi, Taghi Golmohammadi, Mohammad Askari, Asaad Azarnejad, Sadegh Alipoor, Aliasghar Valipour and Kazem Mousavizadeh

Summary

Background: Oxidative stress induced by superoxide anion plays critical roles in the pathogenesis of coronary artery disease (CAD) and hence acute myocardial infarction (AMI). The major source of superoxide production in vascular smooth muscle and endothelial cells is the NADPH oxidase complex. An essential component of this complex is p22phox, that is encoded by the cytochrome b-245, alpha polypeptide (CYBA) gene. The aim of this study was to investigate the association of CYBA variants (rs1049255 and rs4673) and premature acute myocardial infarction risk in an Iranian population.

Methods: The study population consisted of 158 patients under the age of 50 years, with a diagnosis of premature AMI, and 168 age-matched controls with normal coronary angiograms. Genotyping of the polymorphisms was performed by the polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP).

Results: There was no association between the genotypes and allele frequencies of rs4673 polymorphism and premature acute myocardial infarction (P>0.05). A significant statistical association was observed between the genotypes distribution of rs1049255 polymorphism and AMI risk (P=0.037). Furthermore, the distribution of AA+AG/GG genotypes was found to be statistically significant between the two groups (P=0.011).

Conclusions: Our findings indicated that rs1049255 but not rs4673 polymorphism is associated with premature AMI.